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| 尾静脉注射骨髓基质细胞和腹腔注射粒细胞集落刺激因子治疗大鼠脑梗死 | |
| 引用本文： | 顾平,张忠霞,周美刚,王彦永,董慈,崔冬生,耿媛,王铭维.尾静脉注射骨髓基质细胞和腹腔注射粒细胞集落刺激因子治疗大鼠脑梗死[J].中国组织工程研究与临床康复,2011,15(40):7520-7524. |
| 作者姓名： | 顾平 张忠霞 周美刚 王彦永 董慈 崔冬生 耿媛 王铭维 |
| 作者单位： | 1. 河北省脑老化与认知神经科学实验室,河北省石家庄市,050031;河北医科大学第一医院神经内科,河北省石家庄市,050031 2. 河北省脑老化与认知神经科学实验室,河北省石家庄市,050031 3. 河北医科大学第一医院神经内科,河北省石家庄市,050031 |
| 基金项目： | 河北省应用基础研究计划重点基础研究项目 |
| 摘 要： | 背景:骨髓间充质干细胞具有成神经分化特性,有很多试验也证实粒细胞集落刺激因子可以用于改善脑梗死后的神经功能。目的:比较静脉移植骨髓间充质干细胞和腹腔注射粒细胞集落刺激因子动员干细胞来治疗大脑中动脉闭塞模型大鼠疗效。方法:实验以改良的Zea-longa线栓法阻断大脑中动脉建立SD大鼠脑梗死模型,造模24h后分别通过尾静脉注射骨髓间充质干细胞或腹腔注射粒细胞集落刺激因子。结果与结论:两种治疗方法均可改善脑梗死模型大鼠的运动和认知功能,且粒细胞集落刺激因子对脑梗死模型大鼠的运动和认知功能的改善比尾静脉注射骨髓间充质干细胞明显,移植后第7,14天,粒细胞集落刺激因子组梗死面积小于骨髓间充质干细胞组(P<0.05),粒细胞集落刺激因子组BrdU阳性细胞数多于骨髓间充质干细胞组(P<0.05)。提示粒细胞集落刺激因子动员骨髓干细胞治疗脑梗死的疗效可能优于骨髓间充质干细胞静脉注射的移植方法。 |
| 关 键 词： | 骨髓基质细胞 移植 粒细胞集落刺激因子 缺血性脑血管病 中动脉闭塞模型 |
Tail vein injection of bone marrow stromal cells versus intraperitoneal injection of granulocyte colony-stimulating factor in the treatment of cerebral infarction in rats |
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| Gu Ping,Zhang Zhong-xia,Zhou Mei-gang,Wang Yan-yong,Dong Ci,Cui Dong-sheng,Geng Yuan,Wang Ming-wei.Tail vein injection of bone marrow stromal cells versus intraperitoneal injection of granulocyte colony-stimulating factor in the treatment of cerebral infarction in rats[J].Journal of Clinical Rehabilitative Tissue Engineering Research,2011,15(40):7520-7524. | |
| Authors: | Gu Ping Zhang Zhong-xia Zhou Mei-gang Wang Yan-yong Dong Ci Cui Dong-sheng Geng Yuan Wang Ming-wei |
| Affiliation: | Gu Ping1,2,Zhang Zhong-xia1,Zhou Mei-gang2,Wang Yan-yong1,Dong Ci2,Cui Dong-sheng1,Geng Yuan1,Wang Ming-wei1,2 1Brain Aging and Cognitive Neuroscience Laboratory of Hebei Province,Shijiazhuang 050031,Hebei Province,China,2Department of Neurology,First Hospital of Hebei Medical University |
| Abstract: | BACKGROUND: Bone marrow stem cells (BMSCs) possess the potency of transverse differentiation and the character of nerve formation. There are a few researches at intravenous BMSCs and intraperitoneal injection of granulocyte colony stimulating factor (G-CSF) to mobilize stem cells on treatment of cerebral artery occlusion model (MCAO) in rats. OBJECTIVE: To compare the effects of tail vein injection of BMSCs versus intraperitoneal injection of G-CSF in the treatment of cerebral infarction in rats. METHODS: I... |
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