| 结肠癌干细胞表面标志的研究和信号传导 |
| |
| 引用本文： | 陈远崇.结肠癌干细胞表面标志的研究和信号传导[J].中国组织工程研究与临床康复,2011,15(45). |
| |
| 作者姓名： | 陈远崇 |
| |
| 作者单位： | 张家口市第五医院普通外科,河北省张家口市,075000 |
| |
| 摘 要： | 背景:近年来研究表明,结肠癌干细胞参与肿瘤的复发和转移,为恶性肿瘤靶向治疗带来新的希望.目的:探讨结肠癌干细胞特异表面标志的分离和鉴定方法,以及与结肠癌干细胞研究紧密相关的信号通路.方法:以"结肠癌干细胞,肿瘤干细胞,细胞表面标志,信号传导"为中文关键词,以"colon cancer stem cell,cancer stem cell,cell surface sign,signal transduction"为英文关键词,采用计算机检索Medline和CNKI数据库2000-01/2011-06有关结肠癌干细胞表面标志和信号传导的相关文章,排除重复研究或Meta分析类文章,筛选纳入40篇文献进行评价.结果与结论:CD133+与CD44+可作结肠癌干细胞的表面标志.与结肠癌干细胞紧密相关的信号通路有Wnt和Notch等,Wnt信号通路在干细胞内环境稳定中起重要作用,Notch信号通路是干细胞信号网络的重要通路.通过研究结肠癌干细胞的表面标志,可以及早地检测出肿瘤的存在;掌握结肠癌干细胞的生物学特性和信号转导路径,可减少肿瘤的复发,为结肠癌的诊断和治疗降低难度.
|
| 关 键 词： | 结肠癌干细胞 细胞表面标志 细胞信号传导 组织工程 |
Colon cancer stem cell surface markers and signal transduction research |
| |
| Chen Yuan-chong.Colon cancer stem cell surface markers and signal transduction research[J].Journal of Clinical Rehabilitative Tissue Engineering Research,2011,15(45). |
| |
| Authors: | Chen Yuan-chong |
| |
| Affiliation: | Chen Yuan-chong Department of General Surgery,Fifth Hospital of Zhangjiakou City,Zhangjiakou 075000,Hebei Province,China |
| |
| Abstract: | BACKGROUND:In recent years,studies have shown that colon cancer stem cells are involved in tumor recurrence and metastasis,which have brought a new hope for cancer targeted therapy.OBJECTIVE:To investigate the isolation and identification method of colon cancer stem cell surface markers as well as relevant signal transduction pathways.METHODS:A computer-based search of Medline and CNKI databases(2000-01/2011-06) was performed to retrieve colon cancer stem cell surface markers and signal transduction using t... |
| |
| Keywords: | |
| 本文献已被 CNKI 万方数据 等数据库收录！ |
|
