|
|||||
|
|
| 去卵巢牙周炎模型大鼠牙槽骨吸收与补骨脂的干预 | |
| 引用本文： | 朱建华,迟玉红,张艳秋,刘继光.去卵巢牙周炎模型大鼠牙槽骨吸收与补骨脂的干预[J].中国组织工程研究与临床康复,2011,15(41). |
| 作者姓名： | 朱建华 迟玉红 张艳秋 刘继光 |
| 作者单位： | 1. 佳木斯大学附属口腔医院,黑龙江省佳木斯市,154007 2. 齐齐哈尔医学院附属第三医院口腔科,黑龙江省齐齐哈尔市,161000 3. 佳木斯大学科技处,黑龙江省佳木斯市,154007 |
| 基金项目： | 教育部科学技术研究项目 |
| 摘 要： | 背景:补骨脂在治疗骨质疏松症方面有明显效果.目的:观察补骨脂对去卵巢牙周炎大鼠牙槽骨代谢、牙槽骨密度及高度的影响.方法:将30只雌性Wistar 大鼠随机等分为3 组:去卵巢组和补骨脂组行双侧卵巢切除术,假手术组仅手术不切除卵巢,补骨脂组于卵巢切除第2 天灌胃3 g/kg 补骨脂水剂,1次/d.去卵巢2周,所有大鼠采用结扎上颌磨牙的方法建立牙周炎1540007,模型结果与结论:上颌磨牙结扎12 周,与假手术组比较,去卵巢组大鼠血清雌二醇、钙离子浓度显著降低(P < 0.05),碱性磷酸酶水平显著升高(P < 0.05),X 射线片及苏木精-伊红染色显示去卵巢组大鼠上颌骨骨密度及高度显著降低(P < 0.05) ;与去卵巢组比较,补骨脂组大鼠血清钙离子浓度显著升高(P < 0.05),碱性磷酸酶水平显著降低(P < 0.05),上颌骨骨密度及高度显著增高(P < 0.05),且与假手术组比较差异无显著性意义(P > 0.05).说明雌激素缺乏促进实验性牙周炎大鼠牙槽骨吸收,补骨脂可有效阻止雌激素降低导致的牙槽骨高度、骨密度降低. |
| 关 键 词： | 补骨脂 雌激素 牙周炎 牙槽骨 骨质疏松 |
Effects of psoralea corylifolia on alveolar bone absorption in an ovariectimized rat model of periodontitis |
|
| Zhu Jian-hua,Chi Yu-hong,Zhang Yan-qiu,Liu Ji-guang.Effects of psoralea corylifolia on alveolar bone absorption in an ovariectimized rat model of periodontitis[J].Journal of Clinical Rehabilitative Tissue Engineering Research,2011,15(41). | |
| Authors: | Zhu Jian-hua Chi Yu-hong Zhang Yan-qiu Liu Ji-guang |
| Institution: | Zhu Jian-hua1,Chi Yu-hong2,Zhang Yan-qiu1,Liu Ji-guang3 1Stomatology Hospital,Jiamusi University,Jiamusi 1540007,Heilongjiang Province,China,2Department of Stomatology,Third Affiliated Hospital,Qiqihar Medical University,Qiqihar 161000,China 3Office of Science and Technology |
| Abstract: | BACKGROUND:Psoralea corylifolia exhibits obvious therapeutic effects on osteoporosis.OBJECTIVE:To investigate the effects of psoralea corylifolia on alveolar bone metabolism,alveolar bone mineral density and height in ovariectimized rats with periodontitis.METHODS:Thirty female Wister rats were randomly divided into three groups:ovariectomy,psoralea corylifolia and sham-surgery.Rats from the ovariectomy and psoralea corylifolia groups underwent bilateral ovariectomy,and rats from the sham surgery group did ... |
| Keywords: | |
| 本文献已被 CNKI 万方数据 等数据库收录！ | |