| 恒河猴移植肝组织内细胞间黏附分子1与急性排斥反应的关系 |
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| 引用本文： | 冉江华,张升宁,刘静,李铸,吴淑媛,李来邦,张熙冰,张鸿青,李立.恒河猴移植肝组织内细胞间黏附分子1与急性排斥反应的关系[J].中国组织工程研究与临床康复,2011,15(44):8171-8174. |
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| 作者姓名： | 冉江华 张升宁 刘静 李铸 吴淑媛 李来邦 张熙冰 张鸿青 李立 |
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| 作者单位： | 昆明市第一人民医院暨昆明医学院附属甘美医院肝胆胰一科、云南省器官移植研究所肝移植研究中心,云南省昆明市,650011 |
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| 基金项目： | 昆明市科技局重大项目(08S100304)~~ |
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| 摘 要： | 背景:在急性排斥反应发生时会伴有移植组织中细胞间黏附分子1表达水平的增高。目的:探讨恒河猴移植肝组织内细胞间黏附分子1与急性排斥反应的关系。方法:建立恒河猴同种异体肝移植模型,随机分为实验组(移植后不给予抗排斥处理)和对照组(移植中及移植后均给予抗排斥处理)。结果与结论:实验组移植后24,72h血清丙氨酸氨基转移酶及血清总胆红素水平明显高于对照组(P<0.05或<0.001)。移植后12h实验组移植肝即表现为轻度急性排斥反应,说明急性排斥反应时肝功能变化滞后于肝组织病理学检查,移植后24,72h表现为中重度急性排斥反应。移植后6h实验组肝组织中血管内皮细胞、肝细胞膜、胆管上皮细胞上细胞间黏附分子1的表达呈持续增强,并显著高于对照组(P<0.05),随细胞间黏附分子1的表达增强,排斥反应加剧,说明在急性排斥反应早期,肝功能、病理学仅有轻微改变时,细胞间黏附分子1水平即显著升高。提示移植肝组织中细胞间黏附分子1表达的检测对肝移植后急性排斥反应的早期诊断具重要意义。
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| 关 键 词： | 细胞间黏附分子1 肝移植 急性排斥反应 灵长类动物 恒河猴 |
Interrelations between acute rejection and intercellular adhesion molecule-1 in liver tissue after liver transplantation in Rhesus monkey |
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| Ran Jiang-hua,Zhang Sheng-ning,Liu Jing,Li Zhu,Wu Shu-yuan,Li Lai-bang,Zhang Xi-bing,Zhang Hong-qing,Li Li.Interrelations between acute rejection and intercellular adhesion molecule-1 in liver tissue after liver transplantation in Rhesus monkey[J].Journal of Clinical Rehabilitative Tissue Engineering Research,2011,15(44):8171-8174. |
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| Authors: | Ran Jiang-hua Zhang Sheng-ning Liu Jing Li Zhu Wu Shu-yuan Li Lai-bang Zhang Xi-bing Zhang Hong-qing Li Li |
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| Institution: | Ran Jiang-hua,Zhang Sheng-ning,Liu Jing,Li Zhu,Wu Shu-yuan,Li Lai-bang,Zhang Xi-bing,Zhang Hong-qing,Li Li First Department of Hepatopancreatobiliary Surgery,Affiliated Ganmei Hospital of Kunming Medical College and First Hospital of Kunming City,Research Center of Liver Transplantation,Yunnan Province Institute of Organ Transplantation,Kunming 650011,Yunnan Province,China |
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| Abstract: | BACKGROUND: Intercellular adhesion molecule-1 (ICAM-1) level in transplanted tissue would increase when acute rejection occurs. OBJECTIVE: To investigate the relationship between ICAM-1 and acute rejection of liver transplantation in Rhesus Monkey. METHODS: Allogenic liver transplantation models were established in Rhesus monkey and then randomly divided into an experimental group (without anti-rejection management after liver transplantation) and a control group (with anti-rejection management during and a... |
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