| 多孔钛修复兔桡骨骨缺损 |
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| 引用本文： | 张红芳,赵超勇,范红松,张晖,裴福兴,王光林. 多孔钛修复兔桡骨骨缺损[J]. 中国组织工程研究与临床康复, 2011, 15(42). DOI: 10.3969/j.issn.1673-8225.2011.42.004 |
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| 作者姓名： | 张红芳 赵超勇 范红松 张晖 裴福兴 王光林 |
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| 作者单位： | 1. 四川大学华西医院骨科,四川省成都市,610041
2. 四川大学国家生物医学材料工程技术研究中心,四川省成都市,610064 |
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| 基金项目： | 国家重点基础研究发展计划(973)资助项目，国家重点科技攻关支撑计划资助项目 |
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| 摘 要： | 背景:已有将多孔钛植入小型骨缺损的报道.目的:验证多孔钛修复兔桡骨节段性骨缺损的疗效.方法:成年健康新西兰大白兔 21只,建立双侧桡骨10 mm缺损模型,骨缺损处分别植入多孔钛和多孔羟基磷灰石材料.结果:材料植入后第4,8,16周取材观察:①4周时多孔钛组和多孔羟基磷灰石组在材料与宿主骨交界处均有少量骨痂形成,第8和16周时孔隙被新生骨组织填充,与自体骨吻合好.②第8,16周时多孔钛组新骨细胞长入量和骨重建效果几乎接近多孔羟基磷灰石组.两组骨面积在新生骨质长入量上差异无显著性意义(P > 0.05).③第8,16周时多孔钛组的最大承载负荷值明显优于多孔羟基磷灰石组.表明多孔钛支架材料可以促进新骨的形成并有利于节段骨缺损的修复.
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| 关 键 词： | 多孔钛 多孔羟基磷灰石 骨缺损 兔 修复 |
Repairing rabbit radial bone defects by porous titanium |
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| Zhang Hong-fang,Zhao Chao-yong,Fan Hong-song,Zhang Hui,Pei Fu-xing,Wang Guang-lin. Repairing rabbit radial bone defects by porous titanium[J]. Journal of Clinical Rehabilitative Tissue Engineering Research, 2011, 15(42). DOI: 10.3969/j.issn.1673-8225.2011.42.004 |
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| Authors: | Zhang Hong-fang Zhao Chao-yong Fan Hong-song Zhang Hui Pei Fu-xing Wang Guang-lin |
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| Affiliation: | Zhang Hong-fang1,Zhao Chao-yong2,Fan Hong-song2,Zhang Hui1,Pei Fu-xing1,Wang Guang-lin1 1Department of Orthopedics,West China Hospital,Sichuan University,Chengdu 610041,Sichuan Province,China,2National Engineering Research Center for Biomaterials,Chengdu 610064 |
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| Abstract: | BACKGROUND: Usage of porous titanium in the repair of bone defects in animal models has been reported. OBJECTIVE: To investigate the therapeutic effects of porous titanium on the recovery of rabbit radial bone defects. METHODS: A total of healthy 21 New Zealand rabbits were artificially made to be bone defect models by resecting the 1 cm substantial ossea with periosteum of both radii. The left anterior limbs were implanted porous titanium, while the right anterior limbs were implanted porous hydroxyapatite... |
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