橄榄油的降脂作用及其作用机制研究

目的探讨橄榄油的降血脂作用及其作用机制。方法将大鼠随机分为基础饲料喂养组、高脂饲料喂养组和高脂饲料加橄榄油组,喂养8周后分别测定其血清中TG、TC、LDL-C、apoA1、apoB、MDA含量、AI及肝脏组织中的TG、TC含量。结果大鼠血清TG、TC、LDL-C、apoA1、apoB、MDA、AI和肝脏组织中TC、TG含量水平均呈现出高脂饲料喂养组>高脂饲料加橄榄油喂养组>基础饲料喂养组(P<0.05)。结论橄榄油能通过调节大鼠的LDL-C、apoA1、apoB、MDA含量和AI降低大鼠的血脂水平。

Lipid-decreasing Effect of Olive Oil and Its Mechanism

Objective To explore lipid-decreasing effect of olive oil and its mechanism.Methods The rats were randomly divided into three groups:basal fed group,hyper fat fed group and hyper fat plus olive oil group.All the groups were fed for 8 weeks and the serum total cholesterol(TC),triglyceride(TG),low-density lipoprotein cholesterol(LDL-C),apoA1,apoB,malonaldehyde(MDA) levels and the liver tissue TG,TC levels were measured in each group.Results The serum TG,TC,LDL-C,apoA1,apoB,MDA levels and AI of three groups were showed a significant difference:hyper fat fed group>hyper fat plus olive oil group>basal fed group(P<0.05);the liver tissue TG,TC levels of three groups were also showed a significant difference:hyper fat fed group>hyper fat plus olive oil group>basal fed group(P<0.05).Conclusion Oliver oil has a marked antihyperlipidemic effect on hyperlipidmia model rats,and it could prevent and treat cardiovascular and cerebrovascular disease.