胆汁肿瘤标志物检测对于胆管远端良恶性狭窄鉴别诊断的价值

目的 探讨ERCP中胆汁肿瘤标志物的检测对于胆管远端良恶性狭窄鉴别诊断的价值.方法 对经手术或病理学确诊的20例胆管远端恶性狭窄,30例胆管远端良性狭窄患者及13例非胆胰疾病志愿者在ERCP或PTC时提取胆汁,采用免疫放射分析法(IRMA)检测胆汁和血清的CA19-9,CEA,AFP含量,评价其诊断价值.结果 当界定值...

The differential diagnostic Values of tumor markers assays during ERCP in benign and malignant distal biliary tract stricture

Objective To explore the differential diagnostic value of tumor marker determination during ERCP for benign and malignant distal biliary tract stricture. Methods Using ERCP or PTC,we collected bile samples from bile ducts in 20 cases with malignant distal biliary tract stricture, 30 cases with benign distal biliary tract stricture, and 13 patients with non-pancreatic and biliary diseases. Radioimmunoassy was used to detect the levels of CA19-9, CEA and AFP in bile and in serum. The result was evaluated for the value in diagnosis of benign and malignant distal biliary tract stricture. Results The cut off of bile CA19-9 was 30,000 u/ ml, the diagnostic sensitivity was 85% which was more sensitive than it in serum(P < 0.05). Combined detection of CA19-9 in bile and in serum could achieve higher diagnostic sensitivity, specificity and accuracy for benign and malignant distal biliary tract stricture. Conclusions During ERCP, detecting CA19-9 levels in bile and serum had higher differential diagnostic value for benign and malignant distal biliary tract stricture.