Dynamic expression of nerve growth factor and its receptor TrkA after subarachnoid hemorrhage in rat brain |
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Institution: | Department of Neurosurgery, the First Afifliated Hospital of Xi’an Jiaotong University, Xi’an, Shaanxi Province, China |
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Abstract: | Delayed ischemic neurologic deifcit after subarachnoid hemorrhage results from loss of neural cells. Nerve growth factor and its receptor TrkA may promote regeneration of neural cells, but their expression after subarachnoid hemorrhage remains unclear. In the present study, a rat model of subarachnoid hemorrhage was established using two injections of autologous blood into the cistern magna. Immunohisto-chemical staining suggested that the expression of nerve growth factor and TrkA in the cerebral cortex and brainstem increased at 6 hours, peaked at 12 hours and decreased 1 day after induction of subarachnoid hemorrhage, whereas the expression in the hippocampus increased at 6 hours, peaked on day 1, and decreased 3 days later. Compared with those for the rats in the sham and saline groups, neurobehavioral scores decreased signiifcantly 12 hours and 3 days after subarachnoid hemorrhage (P<0.05). These results suggest that the expression of nerve growth factor and its receptor TrkA is dynamically changed in the rat brain and may thus participate in neuronal survival and nerve regeneration after subarachnoid hemorrhage. |
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Keywords: | nerve regeneration subarachnoid hemorrhage nerve growth factor TrkA intrinsic dynamic expression cortex hippocampus brainstem acute phase neural regeneration |
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