Antioxidative mechanism of Lycium barbarum polysaccharides promotes repair and regeneration following cavernous nerve injury |
| |
| Affiliation: | 1. Department of Urology, Zhongnan Hospital, Wuhan University, Wuhan, Hubei Province, China;2. Department of Medical Biochemistry, Basic Medical School, Jining Medical University, Jining, Shandong Province, China;3. Department of Nutrition and Food Health, School of Public Health, Wuhan University, Wuhan, Hubei Province, China |
| |
| Abstract: | Polysaccharides extracted from Lycium barbarum exhibit antioxidant properties. We hypothesized that these polysaccharides resist oxida-tive stress-induced neuronal damage following cavernous nerve injury. In this study, rat models were intragastrically administered Lycium barbarum polysaccharides for 2 weeks at 1, 7, and 14 days after cavernous nerve injury. Serum superoxide dismutase and glutathione peroxidase activities signiifcantly increased at 1 and 2 weeks post-injury. Serum malondialdehyde levels decreased at 2 and 4 weeks. At 12 weeks, peak intracavernous pressure, the number of myelinated axons and nicotinamide adenine dinucleotide phosphate-diaphorase-pos-itive nerve ifbers, levels of phospho-endothelial nitric oxide synthase protein and 3-nitrotyrosine were higher in rats administered at 1 day post-injury compared with rats administered at 7 and 14 days post-injury. These ifndings suggest that application of Lycium barbarum polysaccharides following cavernous nerve crush injury effectively promotes nerve regeneration and erectile functional recovery. This neu-roregenerative effect was most effective in rats orally administered Lycium barbarum polysaccharides at 1 day after cavernous nerve crush injury. |
| |
| Keywords: | nerve regeneration erectile dysfunction cavernous nerve Lycium barbarum polysaccharides oxidative stress superoxide dismutase glutathione peroxidase malondialdehyde intracavernous pressure neural regeneration |
| 本文献已被 CNKI 万方数据 等数据库收录！ |
|
