Early acquisition of TT virus (TTV) in an area endemic for TTV infection |
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Authors: | Davidson F MacDonald D Mokili J L Prescott L E Graham S Simmonds P |
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Affiliation: | Edinburgh and South East Scotland Blood Transfusion Service, University of Edinburgh, Edinburgh, EH8 9AH United Kingdom. |
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Abstract: | TT virus (TTV) is widely distributed, with high frequencies of viremia in South America, Central Africa, and Papua New Guinea. The incidence and timing of infection in children born in a rural area of the Democratic Republic of Congo was investigated. TTV viremia was detected in 61 (58%) of 105 women attending an antenatal clinic and in 36 (54%) of 68 infants. Most infants acquired the infection at >/=3 months postpartum. Surprisingly, TTV infection was detected in a large proportion of children with TTV-negative mothers (13 [43%] of 30). Nucleotide sequences of TTV-infected children were frequently epidemiologically unlinked to variants detected in the mother. These three aspects contrast with the maternal transmission of hepatitis G virus/GB virus C in this cohort and suggest an environmental source of TTV infection comparable to hepatitis A virus and other enterically transmitted infections. |
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