星状神经节阻滞联合普瑞巴林治疗胸背部带状疱疹病理性神经痛的临床研究

目的:观察普瑞巴林联合星状神经节阻滞治疗胸背部带状疱疹病理性神经痛的疗效和安全性。方法:120例胸背部带状疱疹病理性神经痛的患者,按入组顺序随机分为3组:A组:星状神经节阻滞治疗;B组:口服普瑞巴林治疗;C组:普瑞巴林联合星状神经节阻滞治疗。治疗中,B组和C组口服普瑞巴林,剂量为每次150 mg,bid,连续服用8周。结果:治疗后,3组的NRS评分均明显降低(P<0.05);B组和C组的NRS评分相当,组间比较无显著差异;但B组和C组的NRS评分均较A组明显降低(P<0.05)。不良反应主要是声音嘶哑、局部血肿、头晕、嗜睡和水肿。结论:普瑞巴林联合星状神经节阻滞治疗胸背部带状疱疹病理性神经痛安全有效。

Clinical study on stellate ganglion block combined with pregabalin for treating postherpetic neuralgia at chest and back

Objective:To observe the efficacy and safety of stellate ganglion block combined with pregabalin for treating postherpetic neuralgia(PHN) at chest and back.Methods:One hundred and twenty patients with PHN due to breast-back shingles were randomly divided into three groups: group A,receiving stellate ganglion block therapy,group B,receiving pregabalin treatment and group C,receiving stellate ganglion block and pregabalin treatment.The patients in group B and C took pregabalin orally at a dose of 150 mg bid for 8 weeks.Results: After treatment,the NRS scores of the three groups were significantly decreased(P<0.05);group B and C had similar NRS scores(P>0.05);but the NRS scores of group B and C were significantly lower than that of group A(P<0.05).The main adverse reactions were hoarseness,local hematoma,dizziness,sleepiness and edema.Conclusion:Stellate ganglion block combined with pregabalin is a safe and effective method for treating PHN at chest and back.