| 共研磨法改善水飞蓟素固体分散体的溶出度 |
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| 引用本文： | 马林,方伟,苏玉永,于捷飞,刘亚妮. 共研磨法改善水飞蓟素固体分散体的溶出度[J]. 中国医院药学杂志, 2012, 0(17): 1361-1365 |
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| 作者姓名： | 马林 方伟 苏玉永 于捷飞 刘亚妮 |
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| 作者单位： | 华中科技大学同济医学院附属协和医院药剂科;湖北省农业科学院生物农药工程研究中心;湖北省食品药品监督检验研究院 |
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| 摘 要： | 目的:通过共研磨技术改善水飞蓟素固体分散体的体外溶出度。方法:设计单因素试验考察溶出度的影响因素,如共研磨载体材料的种类及与共研磨药物的比例,研磨的时间等因素。结果:以甘露醇与PVP K30为混合亲水性载体材料,与药物的比例为1∶1∶1,研磨6 h,以pH7.4的磷酸盐缓冲溶液为溶出介质。结论:共研磨法制备水飞蓟素固体分散体能显著提高药物的体外溶出度,且制备工艺简单易行。
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| 关 键 词： | 水飞蓟素 共研磨 溶出度 固体分散 |
Study on the improvement in the dissolution of silymarin solid dispersion prepared by co-grinding method |
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| MA Lin,FANG Wei,SU Yu-yong,YU Jie-fei,LIU Ya-ni. Study on the improvement in the dissolution of silymarin solid dispersion prepared by co-grinding method[J]. Chinese Journal of Hospital Pharmacy, 2012, 0(17): 1361-1365 |
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| Authors: | MA Lin FANG Wei SU Yu-yong YU Jie-fei LIU Ya-ni |
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| Affiliation: | 1(1.Union Hospital,Tongji Medical College,Huazhong University of Science and Technology,Hubei Wuhan 430022,China;2.Center of Bio-pesticide Engineering Research,Hubei Academy of Agricultural Science,Hubei Wuhan 430064,China;3.Hubei Institute for Food and Drug Control,Hubei Wuhan 430064,China) |
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| Abstract: | OBJECTIVE To improve the dissolution rate of silymarin solid dispersion in vitro by using co-grinding technology.METHODS Single-factor test was employed to investigate the influencing factors of dissolution,such as phases of co-grinding,category of excipients,ratio of silymarin to co-grinding excipients,time of co-grinding,method of dissolution and so on.RESULTS Used mannitol and PVP K30 as complex carriers and silymarin/mannitol/PVP K30 ratio was 1∶1∶1.Time of co-grinding was 6 h and dissolution medium was phosphate buffer(pH 7.4).CONCLUSION The silymarin solid dispersion prepared by co-grinding method can greatly improve the dissolution.The formulation and technique are simple and can be applicable in production. |
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| Keywords: | silymarin co-grinding dissolution solid dispersion |
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