Monocytic HLA DR antigens in schizophrenic patients |
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Authors: | Krause Daniela Wagner Jenny Matz Judith Weidinger Elif Obermeier Michael Riedel Michael Gruber Rudolf Schwarz Markus Mueller Norbert |
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Affiliation: | a Department of Psychiatry, Ludwig-Maximilians University Munich, Nußbaumstr. 7, 80336 Munich, Germany b Department of Internal Medicine, Ludwig-Maximilians University Munich, Nußbaumstr. 7, 80336 Munich, Germany |
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Abstract: | A genetic association of specific human leukocyte antigens (HLA) DR genes and schizophrenia has recently been shown. These HLA play a fundamental role in the control of immune responses. Furthermore infectious agents have been proposed to be involved in the pathogenesis of schizophrenia. In this study we investigated the rate of HLA DR positive monocytes in schizophrenic patients compared to controls with a special focus on the adaption to in vitro stimulation with toll-like receptor ligands.Patients with schizophrenia and matched controls were included. For each individual, we evaluated the rate of HLA DR positive monocytes (either incubated at 37 °C or after stimulation with lipopolysaccharide or Poly I:C).We found a significantly higher percentage of schizophrenic patients with elevated HLA DR positive cells (p = 0.045) as compared to controls. The adjustment rate from baseline levels of monocytic HLA DR positive cells to stimulation with Poly I:C was significantly lower in schizophrenic patients (p = 0.038).The increased monocytic HLA DR in schizophrenic patients and the maladjustment of their monocytic HLA DR levels to an infectious stimulus might be a sign for a disturbed monocytic immune balance in schizophrenic individuals. |
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Keywords: | BFA, Brefeldin A CD, cluster of differentiation CK, creatine kinase CPDA, citrate phosphate dextrose adenine CRP, C-reactive protein DSM-IV, diagnostic and statistical manual HLA, human leukocyte antigens IL, interleukin LPS, lipopolysaccharide MHC, major histo-compatibility complex PANSS, positive and negative symptoms scale PFA, paraformaldehyde Poly I:C, polyinosinic:polycytidylic acid TLR, toll-like receptor |
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