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Involvement of the paraventricular nucleus (PVN) of hypothalamus in the cardiovascular alterations to head up tilt in conscious rats |
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| Authors: | de Andrade Ozahyr Amarante Marlusa Karlen da Cunha Natália Veronez de Aguiar Corrêa Fernando Morgan Fontes Marco Antonio Peliky Martins-Pinge Marli Cardoso |
| Institution: | a Department of Physiological Sciences, State University of Londrina, Londrina, PR, Brazil b Department of Pharmacology, School of Medicine of Ribeirão Preto, University of São Paulo, Ribeirão Preto, SP, Brazil c Department of Physiology and Biophysics, Federal University of Minas Gerais, Belo Horizonte, MG, Brazil |
| Abstract: | We evaluated the involvement of paraventricular nucleus (PVN) in the changes in mean arterial pressure (MAP) and heart rate (HR) during an orthostatic challenge (head up tilt, HUT). Adult male Wistar rats, instrumented with guide cannulas to PVN and artery and vein catheters were submitted to MAP and HR recording in conscious state and induction of HUT. The HUT induced an increase in MAP and HR and the pretreatment with prazosin and atenolol blocked these effects. After inhibition of neurotransmission with cobalt chloride (1 mM/100 nl) into the PVN the HR parameters did not change, however we observed a decrease in MAP during HUT. Our data suggest the involvement of PVN in the brain circuitry involved in cardiovascular adjustment during orthostatic challenges. |
| Keywords: | Orthostatic challenge Arterial pressure Heart rate Sympathetic Baroreflex Blood volume Hypotension |
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