Serum 25-hydroxyvitamin D concentration and arterial stiffness among type 2 diabetes |
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Authors: | Lee Jee-In Oh Su-Jin Ha Won-Chul Kwon Hyuk-Sang Sohn Tae-Seo Son Hyun-Shik Cha Bong-Yun |
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Institution: | Division of Endocrinology and Metabolism, Department of Internal Medicine, The Catholic University of Korea, Seoul 137-701, Republic of Korea |
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Abstract: | AimTo evaluate the association between serum 25-hydroxyvitamin D 25(OH)D] and arterial stiffness in patients with type 2 diabetes.MethodsSerum 25(OH)D was measured in a cross-sectional sample of 131 men and 174 women aged 30 years and over in Korea. Arterial stiffness was assessed by pulse wave velocity (PWV) obtained with a VP-2000 pulse wave unit. Fasting plasma glucose, insulin, lipid profile, HbA1c, calcium, phosphorous, and HS-CRP were measured.ResultsThe prevalence of vitamin D deficiency was high (85.9%). Those with lower vitamin D levels had increased PWV. Using multivariate regression analysis, low 25(OH)D concentrations independently predicted PWV (p < 0.001) in people with type 2 diabetes after adjustment for other risk factors such as age, smoking, hypertension, HS-CRP, diabetes duration, hypertension duration, HbA1c, and BMI.ConclusionsVitamin D deficiency is common in type 2 diabetes, and a low 25(OH)D level is significantly associated with increased arterial stiffness in these patients. Vitamin D may influence the development of cardiovascular disease. Clinical intervention studies are needed to clarify whether treatment with vitamin D decreases the risk of cardiovascular disease in patients with type 2 diabetes. |
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Keywords: | 25-Hydroxyvitamin D Arterial stiffness Type 2 diabetes |
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