Familial mixed tumors of the parotid gland |
| |
Authors: | Ahn M S Hayashi G M Hilsinger R L Lalwani A K |
| |
Affiliation: | Department of Otolaryngology-Head and Neck Surgery, University of California, San Francisco, 400 Parnassus Ave, Suite A730, San Francisco, California 94117, USA. |
| |
Abstract: | BACKGROUND: The most common neoplasm of the parotid gland is the pleomorphic adenoma. The familial occurrence of such tumors arising within the parotid gland is rare, with only 3 previous reports in the literature. Bilateral synchronous pleomorphic adenomas of the parotid gland are also uncommon. We report 2 siblings with pleomorphic adenomas of the parotid gland, 1 of whom had bilateral synchronous mixed tumors. Patients and Methods Chromosomal analysis of tumor cells from the sibling with bilateral adenomas revealed the translocation t(3;12)(p21;q15). Chromosome 12q breakpoints have previously been identified in a wide variety of solid tumors including pleomorphic adenomas of the parotid gland. CONCLUSIONS: We discuss bilateral mixed tumors, familial parotid tumors, and the potential for a genetic predisposition for the recurrence of such parotid tumors, as suggested by characteristic chromosomal translocations associated with mixed tumors. |
| |
Keywords: | |
本文献已被 PubMed 等数据库收录! |
|