Leukemia in Fanconi's Anemia: Cytogenetic and Tumor Virus Susceptibility Studies |
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| Authors: | DOSIK, HARVEY HSU, LILLIAN Y. TODARO, GEORGE J. LEE, STANLEY L. HIRSCHHORN, KURT SELIRIO, EVA S. ALTER, AARON A. |
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| Affiliation: | 1 Division of Hematology, Department of Medicine, Maimonides Medical Center,Brooklyn, N.Y., and the Department of Medicine, State University of New York, DownstateMedical Center, Brooklyn, N.Y., the Division of Medical Genetics, Department of Pediatrics,Mount Sinai School of Medicine, New York, N.Y., and the National Cancer institute, NationalInstitutes of Health, Bethesda, Md.
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| Abstract: | Fanconis anemia is an inherited disordercharacterized by multiple congenital abnormalities, chromosome anomalies andirreversible aplastic anemia. Patients,and possibly family members, have beennoted to have an increased incidenceof leukemia and other tumors. A familywith two affected male children, one ofwhom developed acute myelomonocyticleukemia, is described. Chromosomepreparations in both parents showed abnormalities, a previously unreportedfinding. Fibroblast cultures from bothparents and one brother inoculated withSimian Virus 40, a known oncogenicagent, developed increased numbers oftransformed colonies, compared withnormal control cultures similarly inoculated. The presence of chromosome abnormalities and cellular susceptibility tooncogenic agents appear to be relatedto an increased risk of malignancy. Submitted on October 27, 1969 Revised on February 3, 1970 Accepted on March 24, 1970 |
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