首页 | 本学科首页   官方微博 | 高级检索  
     


The vasodilator effect of coronary vascular endothelium in situ: its inactivation by hydroquinone
Authors:R J Bing  M Saeed  A Hartmann
Affiliation:1. Department of Obstetrics and Gynecology, Hospital Universitario Austral, Av., Juan Domingo Perón 1500, Pilar Centro, Provincia de Buenos Aires, Argentina;2. Division of Vascular Surgery and Phlebology, FLENI, Montañeses 2325, Ciudad de Buenos Aires, Argentina;3. Departamento de Educación, Instituto de Efectividad Clínica y Sanitaria (IECS), Dr. Emilio Ravignani 2024, Ciudad de Buenos Aires, Argentina;1. AP-HP, Hôpital Saint-Antoine, Service de médecine interne, Inflammation–Immunopathology–Biotherapy Department (DHU i2B), Sorbonne Universités, UPMC Univ Paris 06, F-75012 Paris, France;2. Université René Descartes, Paris, France;3. APHP, Centre de reference malades auto-immunes et systemiques rares, Service de médecine interne, Hopital Cochin, Paris, France;4. Université Nantes, Nantes, France;5. Service de médecine interne, Hopital Nantes, Nantes, France;6. Rheumatology and Clinical Immunology, Department of Clinical and Experimental Sciences, University of Brescia, Brescia, Italy;7. Department of Obstetrics, Gynaecology, and Pediatrics, Catholic University of Sacred Heart, Rome, Italy;8. Systemic Autoimmune Disease Unit, Department of Internal Medicine I, Vall d''Hebrón University Hospital, Universitat Autonoma de Barcelona, Barcelona, Spain;9. Rheumatology Unit, Department of Medicine, University of Padua, Padua, Italy;10. Department of Rheumatology, University Medical Centre Ljubljana, Slovenia;11. Department of Rheumatology and Clinical Immunology, University Medical Center, Utrecht, Netherlands;12. Université Paris 7, Paris, France;13. AP-HP, Unité Fonctionnelles d''Immunologie «Auto-immunité et Hypersensibilités», Hôpital Bichat-Claude Bernard, Paris, France;14. Université Paris 7, Paris, France;15. AP-HP, Service de gynécologie obstétrique, Hôpital Trousseau Paris, France;p. Université Paris 13, Bondy, France;q. AP-HP, Service de gynécologie-obstétrique, Hôpital Jean Verdier, 93140 Bondy, France
Abstract:Studies were carried out to demonstrate the presence of the endothelium derived relaxing factor (EDRF) in coronary arteries in situ and the effect of hydroquinone on this factor. The studies revealed the presence of EDRF in coronary arteries of rabbit hearts remaining in situ. EDRF was inactivated by left atrial injection of hydroquinone. In situ constriction of coronary arteries by vasopressin was markedly increased following exposure to hydroquinone, and the dilatory response to acetylcholine was absent. The experiments confirm the presence of the endothelium derived relaxing factor in coronary arteries in situ and its inactivation by hydroquinone.
Keywords:
本文献已被 ScienceDirect 等数据库收录!
设为首页 | 免责声明 | 关于勤云 | 加入收藏

Copyright©北京勤云科技发展有限公司  京ICP备09084417号