| 偶氮聚合物作为结肠靶向给药载体的研究进展 |
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| 引用本文： | 陈清元,沈家瑞,陈建海. 偶氮聚合物作为结肠靶向给药载体的研究进展[J]. 中国医药工业杂志, 2002, 33(8): 412-416 |
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| 作者姓名： | 陈清元 沈家瑞 陈建海 |
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| 作者单位： | 1. 第一军医大学化学教研室
2. 华南理工大学材料学院,广东广州,510645 |
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| 摘 要： | 偶氮聚合物中的偶氮键可被结肠菌丛产生的偶氮还原酶催化还原，可用作高定位性的结肠靶向给药药物载体。偶氮聚合物药物释放体系可分为水凝胶骨架制剂、包衣制剂和聚合物前药体系。本文综述了这几方面的偶氮聚合物的研究进展。
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| 关 键 词： | 结肠靶向 药物载体 偶氮聚合物 偶氮还原 |
| 文章编号： | 1001-8255(2002)08-0412-05 |
| 修稿时间： | 2000-10-17 |
Azo Polymers for Colon-specific Drug Delivery |
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| CHEN Qing Yuan ,SHEN Jia Rui ,CHEN Jian Hai. Azo Polymers for Colon-specific Drug Delivery[J]. , 2002, 33(8): 412-416 |
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| Authors: | CHEN Qing Yuan SHEN Jia Rui CHEN Jian Hai |
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| Affiliation: | CHEN Qing Yuan 1,SHEN Jia Rui 2,CHEN Jian Hai 1 |
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| Abstract: | Azo polymers may be expected as colon specific drug delivery systems because azo bonds in polymers can be reduced by azoreductase generated by colonic bacteria. On the basis of the synthetic methodology and the resulting delivery forms, the azo polymer colonic targeting systems are classified as hydrogels, coating systems and polymeric prodrugs. |
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| Keywords: | colon specific drug carrier azo polymer azo reduction |
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