迟发性维生素K缺乏性颅内出血患儿血浆心钠素与低钠血症的关系

目的探讨迟发性维生素K缺乏性颅内出血患儿心钠素(ANP)水平变化与低钠血症的关系及其临床意义。方法应用放射免疫分析技术检测108例颅内出血患儿不同病程的血浆ANP水平,同时检测血清钠的含量,选取25例健康同龄儿作为对照。结果(1)颅内出血急性期血浆ANP水平均高于对照组(P<0·05);昏迷组患儿ANP升高更明显(P<0·01);(2)颅内出血患儿血浆ANP与血清钠水平呈负相关(γ=-0·748,P<0·05)。结论(1)迟发性维生素K缺乏性颅内出血患儿血浆ANP水平反映脑损伤严重程度;(2)ANP参与迟发性维生素K缺乏性颅内出血患儿低钠血症的形成过程。

Relationship between atrial natriuretic peptide and hyponatremia in delayed vitamin K deficiency children with intracranial hemorrhage

Objective To investigate the clinical significance of atrial natriuretic peptide (ANP) in delayed vitamin K deficiency children with intracranial hemorrhage.Methods The plasma ANP levels in 108 delayed vitamin K deficiency children with intracranial hemorrhage and 25 controls were measured by radioimmunoassay.Meanwhile,the serum sodium was examined.Results (1) The plasma ANP level of patients with acute intracranial hemorrhage was higher than that of control group (P<0.05) and comatose group showed even higher plasma ANP level.(2) The plasma ANP levels were negatively correlated with the serum sodium (r=-0.748,P<0.05).Conclusion (1) The ANP level of plasma in patients with intracranial hemorrhage is related to the severity of brain damage.(2) ANP may be invloved in the pathogenesis of hyponatremia.