| 苯骈吡喃酮肟类化合物的生物活性及定量构效关系研究 |
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| 引用本文： | 苯骈吡喃酮肟类化合物的生物活性及定量构效关系研究[J]. 中国药科大学学报, 1998, (5): 6-10. |
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| 作者姓名： | 黄文龙 吴苏敏 |
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| 作者单位： | 中国药科大学新药研究中心 |
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| 摘 要： | 根据苯骈吡喃类钾通道启开剂的构效关系，设计合成了１６个苯骈吡喃酮肟类化合物，测试体内外生物活性，并用逐步判别分析方法研究了该类化合物的构效关系
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| 关 键 词： | 钾通道启开剂 苯骈吡喃 逐步判别分析 定量构效关系 |
Studies on the Bioactivity and QSAR of Some Benzopyran 4 one Oximes |
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| Studies on the Bioactivity and QSAR of Some Benzopyran 4 one Oximes[J]. Journal of China Pharmaceutical University, 1998, (5): 6-10. |
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| Authors: | Huang Wenlong Wu Sumin Yan Zheng Ji Nianning Peng Sixun Division of Medicinal Chemistry China Pharmaceutical University Nanjing |
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| Affiliation: | Huang Wenlong,Wu Sumin,Yan Zheng,Ji Nianning,Peng Sixun Division of Medicinal Chemistry,China Pharmaceutical University,Nanjing 210009 |
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| Abstract: | Benzopyran 4 one oximes were synthesized and evaluated for their bioactivity in vivo and in vitro QSAR was studied by stepwise discriminant analysis on the basis of the calculated structural parameters and bioactivity of vasodilation in vitro and hypotension in vivo |
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| Keywords: | Benzopyrans Stepwise discriminant analysis QSAR Potassium channel operer (PCO) |
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