复方苦参注射液配伍合理性

目的: 探讨苦参与白土苓配伍的合理性。 方法: 采用小鼠体内抑瘤、镇痛、止血、抗炎四种模型,比较复方苦参注射液(含生药15,7.5,3.75 g·kg^-1)、苦参注射液(含生药10.5,5.25,2.63 g·kg^-1)、白土苓注射液(含生药4.5,2.25,1.13 g·kg^-1)与药效的关系。 结果: 复方苦参注射液、苦参注射液具有明显的体内抑瘤(高、中剂量)、镇痛(高、中剂量)、抗炎(高剂量)作用和止血作用(高剂量);白土苓注射液仅有一定的镇痛(高、中剂量)、缩短凝血时间(高剂量)作用;苦参与白土苓配伍为复方苦参注射液后,可增强苦参的抑瘤作用(高、中、低剂量),可提高苦参的镇痛作用强度和作用时间,缩短凝血时间(高剂量)和出血时间(高剂量),并提高苦参的抗炎作用(高、中、低剂量)。 结论: 苦参和白土苓配伍应用具有协同增效作用,表明复方苦参注射液配伍应用具有合理性。

Study on Rationality for Compatibility of Kushen Injection

Objective: To study the rationality for compatibility of Kushen and Baituling. Method: Four mouse models of tumor, pain, hemorrhage and inflammation were used to evaluate the pharmacodynamic effects of Compound Kushen injection (15.75, 3.75 g·kg^-1), Kushen injection (10.5, 5.25, 2.63 g·kg^-1)and Baituling injection (4.5, 2.25, 1.13 g·kg^-1). Result : Compound Kushen injection and Kushen injection showed significant anti-tumor effect (high and middle doses), analgesia (high and middle doses), anti-inflammation (high dose)and hemostasis (high dose) effects. Baituling injection showed effects on analgesia (high and middle doses) and hemostasis (high dose). Compound Kushen injection could enhance the anti-tumor effect and anti-inflammation (three doses) of Kushen, promote the action of analgesia for strengthen and duration, shorten the coagulation time and hemorrhage time (high dose). Conclusion : Kushen and Baituling have synergistic action with compatible rationality in Compound Kushen injection.