| 人类偏肺病毒F蛋白的B细胞表位预测 |
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| 引用本文： | 毛华伟,赵晓东.人类偏肺病毒F蛋白的B细胞表位预测[J].免疫学杂志,2006,22(3):289-293. |
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| 作者姓名： | 毛华伟 赵晓东 |
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| 作者单位： | 重庆医科大学儿童医院免疫学研究室,重庆,400014 |
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| 摘 要： | 目的 预测人类偏肺病毒F蛋白的B细胞表位。方法综合分析二级结构、亲水性、表面可及性与抗原性指数，预测F蛋白的抗原表位。结果B细胞表位位于F蛋白N段15-28、88-102、161-189、195-202、206-213、245-257、290-299、302-309、318-334、410-419、515-526区段。结论应用多参数预测F蛋白的B细胞表位，为进一步研究蛋白特征、单克隆抗体制备及表位疫苗研制奠定了基础。
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| 关 键 词： | 偏肺病毒 F蛋白 B细胞表位 |
| 文章编号： | 1000-8861（2006）03-0289-05 |
| 收稿时间： | 2005-05-17 |
| 修稿时间： | 2005-08-26 |
Prediction of the B cell epitopes of human metapneumovirus fusion protein |
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| MAO Hua-wei,ZHAO Xiao-dong.Prediction of the B cell epitopes of human metapneumovirus fusion protein[J].Immunological Journal,2006,22(3):289-293. |
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| Authors: | MAO Hua-wei ZHAO Xiao-dong |
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| Institution: | Department of Immunology, Chongqing University of Medical Sciences, Chonging 400014, China |
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| Abstract: | Objective To predict the B cell epitopes of human metapneumovirus fusion protein. Methods Based on analysisis of the amino acid sequence and the flexible regions of fusion protein, the B cell epitopes of fusion protein were predicted by methods of Hopp-Woods, Emini, and Jameson-Wolf. Results The B cell epitopes were located at or adjacent to the N-terminal No. 15-28, 88-102, 161-189, 195-202, 206-213, 245-257, 290-299, 302-309, 318-334, 410-419, and 515-526 regions. Conclusion The B cell epitopes of fusion protein is predicted successfully, which establishes the basis for studies of the characterization of the protein, development of epitope-based vaccine, and preparation of monoclonal antibody against fusion protein. |
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| Keywords: | Metapneumovirus F protein B cell epitope |
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