首页 | 本学科首页   官方微博 | 高级检索  
     

人类偏肺病毒F蛋白的B细胞表位预测
引用本文:毛华伟,赵晓东. 人类偏肺病毒F蛋白的B细胞表位预测[J]. 免疫学杂志, 2006, 22(3): 289-293
作者姓名:毛华伟  赵晓东
作者单位:重庆医科大学儿童医院免疫学研究室,重庆,400014
摘    要:目的 预测人类偏肺病毒F蛋白的B细胞表位。方法综合分析二级结构、亲水性、表面可及性与抗原性指数,预测F蛋白的抗原表位。结果B细胞表位位于F蛋白N段15-28、88-102、161-189、195-202、206-213、245-257、290-299、302-309、318-334、410-419、515-526区段。结论应用多参数预测F蛋白的B细胞表位,为进一步研究蛋白特征、单克隆抗体制备及表位疫苗研制奠定了基础。

关 键 词:偏肺病毒  F蛋白  B细胞表位
文章编号:1000-8861(2006)03-0289-05
收稿时间:2005-05-17
修稿时间:2005-08-26

Prediction of the B cell epitopes of human metapneumovirus fusion protein
MAO Hua-wei,ZHAO Xiao-dong. Prediction of the B cell epitopes of human metapneumovirus fusion protein[J]. Immunological Journal, 2006, 22(3): 289-293
Authors:MAO Hua-wei  ZHAO Xiao-dong
Affiliation:Department of Immunology, Chongqing University of Medical Sciences, Chonging 400014, China
Abstract:Objective To predict the B cell epitopes of human metapneumovirus fusion protein. Methods Based on analysisis of the amino acid sequence and the flexible regions of fusion protein, the B cell epitopes of fusion protein were predicted by methods of Hopp-Woods, Emini, and Jameson-Wolf. Results The B cell epitopes were located at or adjacent to the N-terminal No. 15-28, 88-102, 161-189, 195-202, 206-213, 245-257, 290-299, 302-309, 318-334, 410-419, and 515-526 regions. Conclusion The B cell epitopes of fusion protein is predicted successfully, which establishes the basis for studies of the characterization of the protein, development of epitope-based vaccine, and preparation of monoclonal antibody against fusion protein.
Keywords:Metapneumovirus   F protein   B cell epitope
本文献已被 CNKI 维普 万方数据 等数据库收录!
设为首页 | 免责声明 | 关于勤云 | 加入收藏

Copyright©北京勤云科技发展有限公司  京ICP备09084417号