In vitro pharmacodynamic properties of three antifungal agents against preformed Candida albicans biofilms determined by time-kill studies |
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| Authors: | Ramage Gordon VandeWalle Kacy Bachmann Stefano P Wickes Brian L López-Ribot José L |
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| Affiliation: | Department of Microbiology, The University of Texas Health Science Center at San Antonio, San Antonio, Texas 78245, USA. |
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| Abstract: | We have examined the in vitro activities of fluconazole, amphotericin B, and caspofungin against Candida albicans biofilms by time-kill methodology. Fluconazole was ineffective against biofilms. Killing of biofilm cells was suboptimal at therapeutic concentrations of amphotericin B. Caspofungin displayed the most effective pharmacokinetic properties, with > or =99% killing at physiological concentrations. |
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