醒脑静注射液与安宫牛黄丸对脑梗死急性期患者神经功能缺损程度的影响

背景临床实际中,发现以醒脑开窍并益气养阴为治则,标本兼治可明显改善脑梗死急性期患者的神经功能恢复情况.目的观察醒脑静注射液与安宫牛黄丸对脑梗死急性期患者神经功能障碍的影响.设计以患者为观察对象,随机对照.单位中国人民武装警察部队广东总队医院.对象研究对象为武警广东总队医院神经内科1998-09/2003-09住院的脑梗死患者.方法将脑梗死急性期患者120例随机分为醒脑静注射液组和安宫牛黄丸组及丹参粉组,各40例,治疗14 d后分别观察患者的疗效、神经功能改善情况.主要观察指标各组患者神经功能改善情况比较.结果醒脑静注射液组、安宫牛黄丸组、丹参粉组总有效率分别为95%,90%,65%,醒脑静注射液组、安宫牛黄丸组肢体瘫痪的恢复明显优于对照组,醒脑静注射液组疗效显著.结论醒脑静注射液与安宫牛黄丸对脑梗死急性期有较好的治疗作用,而且前者对神经功能缺损的恢复效果更为明显.

Effect of xingnaojing injection and angong niuhuang wan on neurological functional defect in acute stage of cerebral infarction

BACKGROUND: It is discovered in clinical practice that the principles of regaining consciousness, opening orifice combining with benefiting qi and nourishing yin for the treatment of both root causes and symptoms can improve remarkably neurological functional recovery in acute stage of cerebral infarction.OBJECTIVE: To observe the effects of xingnaojing injection and angong niuhuang wan on neurological functional disturbance in acute stage of cerebral infarction.DESIGN: Randomized controlled study based on patients.SETTING: Guangdong General Hospital of Chinese People' s Armed Police Force.PARTICIPANTS: Inpatients with cerebral infarction in Department of Neurology of Guangdong General Hospital, Chinese People' s Armed Police Force from September 1998 to September 2003.METHODS: Totally 120 cases in the acute stage of cerebral infarction were randomized into xingnaojing injection group(XNJ), angong niuhuang wan (ANW) group and danshen fen(DSF) group, 40 cases in each group. Fourteen days after treatment, the therapeutic effects and neurological functional improvement were observed.MEAN OUTCOME MEASURES: Comparison of the improvement in neurological function in groups was carried on in the experiment. RESULTS: The total effective rates were 95%, 90% and 65% in xingnaojing injection group, angong niuhuang wan group and danshen fen group successively. The paralysis of limb was recovered more markedly in xingnaojing injection group and angong niuhuang wan group compared with the control. The therapeutic effect was significant in xingnaojing injection group.CONCLUSION: Both xingnaojing injection group and angong niuhuang wan group treat cerebral infarction of acute stage with better therapeutic effects, and the former provides rather remarkable effect on the recovery of neurological functional defect.