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Stromal Vascular Fraction Transplantation as an Alternative Therapy for Ischemic Heart Failure: Anti-inflammatory Role
Authors:Goditha U Premaratne  Li-Ping Ma  Masatoshi Fujita  Xue Lin  Entela Bollano  Michael Fu
Institution:(1) Wallenberg Laboratory for Cardiovascular Research, Sahlgrenska University Hospital, University of Gothenburg, Gothenburg, Sweden;(2) Department of Cardiology, Shanghai Second Military Medical University, Shanghai, PR China;(3) Department of Human Health Sciences, Graduate School of Medicine, Kyoto University, Kyoto, Japan
Abstract:

Background  

The aims of this study were: (1) to show the feasibility of using adipose-derived stromal vascular fraction (SVF) as an alternative to bone marrow mono nuclear cell (BM-MNC) for cell transplantation into chronic ischemic myocardium; and (2) to explore underlying mechanisms with focus on anti-inflammation role of engrafted SVF and BM-MNC post chronic myocardial infarction (MI) against left ventricular (LV) remodelling and cardiac dysfunction.
Keywords:
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