| 成纤维细胞生长因子2和成纤维细胞生长因子受体1蛋白在慢性应激抑郁大鼠海马中的表达 |
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| 引用本文： | 侯公林,Mingming Tang. 成纤维细胞生长因子2和成纤维细胞生长因子受体1蛋白在慢性应激抑郁大鼠海马中的表达[J]. 中国神经再生研究, 2011, 6(13): 1010-1016 |
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| 作者姓名： | 侯公林 Mingming Tang |
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| 作者单位： | 浙江理工大学心理系,浙江理工大学心理系 |
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| 摘 要： | There is evidence that the expression of members of the fibroblast growth factor(FGF) protein family is altered in post-mortem brains of humans suffering from major depressive disorder.The present study examined whether the expression of fibroblast growth factor-2(FGF2) and fibroblast growth factor receptor-1(FGFR1) protein is altered following chronic stress in an animal model.Rats were exposed to 35 days of chronic unpredictable mild stress,and then tested using open-field and sucrose consumption tests.Compared with the control group,rats in the chronic stress group exhibited obvious depressive-like behaviors,including anhedonia,anxiety and decreased mobility.The results of western blot analysis and immunohistochemical analysis revealed a downregulation of the expression of FGF2 and FGFR1 in the hippocampus of rats,particularly in the CA1,CA3 and dentate gyrus.This decreased expression is in accord with the results of post-mortem studies in humans with major depressive disorder.These findings suggest that FGF2 and FGFR1 proteins participate in the pathophysiology of depressive-like behavior,and may play an important role in the mechanism of chronic stress-induced depression.
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| 关 键 词： | depression hippocampus fibroblast growth factor-2 fibroblast growth factor receptor-1 neural regeneration |
Expression of fibroblast growth factor-2 and fibroblast growth factor receptor-1 protein in the hippocampus in rats exhibiting chronic stress-induced depression |
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| Gonglin Hou and Mingming Tang. Expression of fibroblast growth factor-2 and fibroblast growth factor receptor-1 protein in the hippocampus in rats exhibiting chronic stress-induced depression[J]. Neural Regeneration Research, 2011, 6(13): 1010-1016 |
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| Authors: | Gonglin Hou and Mingming Tang |
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| Affiliation: | Department of Psychology, Zhejiang Sci-Tech University, Hangzhou 310018, Zhejiang Province, China,Department of Psychology, Zhejiang Sci-Tech University, Hangzhou 310018, Zhejiang Province, China |
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| Abstract: | There is evidence that the expression of members of the fibroblast growth factor (FGF) protein family is altered in post-mortem brains of humans suffering from major depressive disorder. The present study examined whether the expression of fibroblast growth factor-2 (FGF2) and fibroblast growth factor receptor-1 (FGFR1) protein is altered following chronic stress in an animal model. Rats were exposed to 35 days of chronic unpredictable mild stress, and then tested using open-field and sucrose consumption tests. Compared with the control group, rats in the chronic stress group exhibited obvious depressive-like behaviors, including anhedonia, anxiety and decreased mobility. The results of western blot analysis and immunohistochemical analysis revealed a downregulation of the expression of FGF2 and FGFR1 in the hippocampus of rats, particularly in the CA1, CA3 and dentate gyrus. This decreased expression is in accord with the results of post-mortem studies in humans with major depressive disorder. These findings suggest that FGF2 and FGFR1 proteins participate in the pathophysiology of depressive-like behavior, and may play an important role in the mechanism of chronic stress-induced depression.Key Words: depression; hippocampus; fibroblast growth factor-2; fibroblast growth factor receptor-1; neural regeneration |
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| Keywords: | Depression Hippocampus FGF2 FGFR1 |
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