| 瘦素受体在睾丸的表达分布及其功能 |
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| 引用本文： | 高龙,陈斌. 瘦素受体在睾丸的表达分布及其功能[J]. 中华男科学杂志, 2009, 15(6): 551-555 |
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| 作者姓名： | 高龙 陈斌 |
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| 作者单位： | 上海交通大学医学院附属仁济医院泌尿外科,上海市男科学研究所,上海,200001 |
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| 摘 要： | 瘦素是肥胖基因的蛋白产物,参与了机体体重和能量调节、免疫调节、血管生成、炎症反应和青春期启动及生殖调节等一系列重要生理活动。瘦素发挥的不同作用与其受体(Ob-R)表达分布的时空特征相关,瘦素在睾丸内发挥着多种重要的生物学作用。本文通过综述Ob-R在大、小鼠及人类睾丸的不同细胞和不同发育阶段以及生理和病理状态下的表达和分布情况,结合已有的体外实验结果,探讨了Ob-R与睾丸功能的关系,希望能为进一步研究人类睾丸的生理发育及男性不育的病理生理机制开拓思路。
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| 关 键 词： | 睾丸 瘦素 受体 分布 功能 |
Expression,Distribution and Biological Function of Leptin Receptor in the Testis |
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| GAO Long,CHEN Bin. Expression,Distribution and Biological Function of Leptin Receptor in the Testis[J]. National journal of andrology, 2009, 15(6): 551-555 |
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| Authors: | GAO Long CHEN Bin |
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| Affiliation: | GAO Long,CHEN Bin Department of Urology,Shanghai Institute of ,rology,Renji Hospital,Shanghai Jiaotong University School of Medicine,Shanghai 200001,China |
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| Abstract: | Leptin,a 167-amino acid peptidic hormone encoded by the obese gene, is known to be involved in the regulation of body fat, energy expenditure, immune function, angiogenesis, inflammatory reaction, the onset of puberty, and the regulation of reproductive function. The roles of leptin vary with different expression and distribution patterns of its receptor Ob-R. This article analyzes the biological effects of leptin and its receptor on the testis by reviewing the expression and distribution of Ob-R in differe... |
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| Keywords: | testis leptin receptor distribution function |
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