重庆地区性传播疾病患者387例支原体培养及药敏试验结果分析

目的了解重庆地区性传播疾病(sexually transmitted disease,STD)患者支原体感染情况及其药物敏感试验结果.方法对387例支原体培养阳性的STD患者的支原体培养及药敏试验结果进行回顾性分析.结果在支原体感染患者中,以20～40岁患者为主要感染人群,男女比例无明显差别;解脲支原体(ureaplasma urealyticum,Uu)为主要病原体;在对9种药物进行的药敏试验结果中,交沙霉素、美满霉素及强力霉素敏感率较高,依次为94.06%、88.89%、86.82%,对克林霉素、阿齐霉素及罗红霉素的耐药率较高.结论对于Uu和人型支原体(Mycoplasma hominis,Mh)感染,临床医生应当结合药敏试验合理应用抗生素.目前重庆地区Uu和Mh感染的治疗可以首选交沙霉素及半合成四环素类抗生素进行治疗.

Culture and drug-sensitivity test of mycoplasma from 387 patients with sexually transmitted disease

Objective To investigate the infection rate and the drug sensitivity of mycoplasma from patients with sexually transmitted disease (STD) in Chonqing. Methods Data from 387 STD patients positive for mycoplasma culture were analyzed retrospectively. Results Among the mycoplasma infected patients, those at the age from 20 to 40 years old were susceptible to mycoplasma infection. There was no significant difference between the male and the female. Ureaplasma urealyticum (UU) was the main pathogen of non gonococcal urethritis (NGU). Results of the drug sensitivity test of the 9 antibiotics showed that the sensitivity rate to josamycin, minocycline and doxycycline was 94.06%, 88.89%, and 86.82%, respectively. However, the resistance rate to clindamycin, azithromycin, and roxithromycin was higher. Conclusion It is important for doctors to use antibiotics for the treatment of UU and/or mycoplasma hominis (Mh) infection based on the results of drug sensitivity test. At present, josamycin, minocycline, and doxycycline may be used as the first antibiotics to treat mycoplasma infection in Chongqing.