LAK细胞的抗肿瘤抗转移作用

由于绝大多数肿瘤细胞的抗原性是十分微弱的,甚至是难以发现的。因此,以识别特异性抗原为其作用基础的T细胞,在肿瘤免疫上的作用便受到了非难和怀疑。免疫监视学说也做了相应修正。最近人们越来越重视非特异性免疫效应细胞的作用,特别是天然杀伤细胞(Natural Killercells,NK)但NK细胞只对某些白血病细胞,淋巴瘤细

Antitumor and Antimetastasis Activity of LAK cells

It has been shown that rat splenocytes incubated in IL-2 beoome lytic for WBT-2M fibrosarcoma cells of WKA rats and for SST-2 mammary carcinoma cells of SHR rats. We have performed the adoptive transfer of such LAK cells in WBT-2M and SST-2 met astasis models to test their in vivo efficacy. The LAK cells infused i. v. into WKA rats with WBT-2M fibrosarcoma and into SHR rats with SST-2 mammary carcinoma, led to marked decrease in the number of pulmonary metastatic nodules and to improve the survival of animals bearing SST-2. The combination of LAK cells and IL-2 provided a more effective antimetatic activity than LAK alone. T^he administration of LAK cells led to significantly decrease in the number of retained and survived tumor cells in lungs. The additional administration of LAK cells on day 3 and day 7 expressed a more marked inhibition of pulmonary metastatic formation of WBT-2M fibrosarcoma ia WKA rats. It was clear that LAK cells are not only able to kill curcular tumor cells, but also to destroy lung-retained tumor cells and the established WBT-2M pulmonary micrometastases. According to the results described above,it suggests that the use of LAK cells may provide a valuable method for the adoptive therapy of human neoplasmas as well.