碳酸化羟基磷灰石-骨界面的生物力学和组织学研究

目的新型骨缺损修复材料碳酸化羟基磷灰石水泥(CHC)植人骨内，检测不同时间12HC-骨界面的生物力学和组织学变化。方法成年雄性杂种犬股骨远端制备分离动物模型，实验组植人CHC，对照组植人聚甲基丙烯酸甲酯骨水泥(PMMA)．观察术后不同时间植人材料．骨界面组织学和生物力学的变化。结果随实验时间的延长，实验组界面结合强度逐渐升高．16周时达到281N，而对照组界面结合强度则逐渐降低。组织学观察表明随实验时间延长。实验组界面CHC逐渐降解。并且新骨逐渐长人，对照组界面形成纤维组织。结论CHC生物相容性良好，能够与骨直接结合并逐渐整合为一体．界面结合力随时间延长逐渐升高。

Biomechanical and Histological Evaluations at Interface between Carbonated Hydroxyapatite Cement and Bone

Objective A newly developed carbonated hydroxyapatite cement (CHC) was used as bone graft biomaterial and implanted into the bone. The biomechanical properties and histological features between CHC and bone were examined at different time points after implantation. Methods Mature male mongrels dogs were used, with CHC implanted into the distal femur as Detaching models' experimental group, while implantation with polymethylmethacrylate (PMMA) as control group. The biomechanical and histological properties at bone-implant interface were evaluated at different time points. Results The maximal bonding strength between CHC and bone increased along with the experimental time, up to 281N at week 16 after implantation. However, the maximal bending strength of the control group showed reverse results. Histologically, the CHC degraded gradually and replaced by new bone tissue, while the control groups showed fibrous tissue between PMMA and bone. Conclusion The CHC had excellent biocompatibility, and was able to integrated with bone directly. The bonding strength between CHC and bone increased with time post implantation.