USP2和CyclinD1蛋白在胃癌中的表达及其临床意义 |
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引用本文: | 叶盛威,王明伟,陈琼荣.USP2和CyclinD1蛋白在胃癌中的表达及其临床意义[J].中国肿瘤,2014,23(3):257-260. |
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作者姓名: | 叶盛威 王明伟 陈琼荣 |
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作者单位: | 湖北省肿瘤医院;湖北省肿瘤医院;湖北省肿瘤医院 |
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基金项目: | 湖北省自然科学基金资助项目(2012FFB01703); |
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摘 要: | 目的]分析胃癌中USP2蛋白和CyclinD1蛋白的表达及其临床意义。方法]应用免疫组化方法检测胃癌组织和相应癌旁组织中USP2蛋白和CyclinD1蛋白的表达情况,并与胃癌临床病理因素进行相关性分析。结果]胃癌组织中USP2蛋白阳性表达率为63.3%(69/109),而癌旁组织中USP2阳性表达率为33.7%(34/101),两组比较有统计学差异(χ^2=18.428,P〈0.001)。胃癌组织中CyclinD1蛋白的阳性表达率为41.1%(49/111)。胃癌组织中USP2表达与CyclinD1表达高度相关(P=0.005);胃癌组织中CyclinD1表达与远处转移和TNM分期呈正相关。结论]胃癌组织中USP2异常表达可能通过其底物蛋白CyclinD1促进胃癌发展并影响患者的预后。
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关 键 词: | 胃癌 USP2 Cyclin D1 远处转移 TNM分期 |
收稿时间: | 2013/10/7 0:00:00 |
Expression of USP2 and CyclinD1 in Gastric Carcinoma and Its Clinicopathologic Significance |
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Institution: | Hu-Bei Province Cancer Hospital |
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Abstract: | Purposel To investigate the USP2 and CyclinD1 expression in gastric carcinoma and their clinicopathologic significance. Methods I The expressions of USP2,CyclinDl in gastric carcinoma tissue and paracancerous tissue were examined by immunohistoehemistry. The relationship of USP2,CyclinD1 proteins and clinicopathologic significance in gastric carcinoma was analyzed. Results] The positive rate of USP2 protein expression in gastric carcinoma and paracancerous tissue was 63.3%(69/109) and 33.7%(33.7/101),respectively with significant difference (X2=18.428 ,P〈 0.001 ).The positive expression rate of CyclinDl protein in gastric carcinoma was 41.1% (49/111). There was significant positive correlation between expression of USP2 and CyclinDl in cancerous tissues(P=0.005). There was also positive correlation between expression of CyclinD1 in cancer tissues and distant metastasis and TNM stage. Conclusion] Abnormal USP2 expression in gastric carcinoma may influence prognosis through CyelinD1 as a substrate. |
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Keywords: | gastric carcinoma USP2 CyclinD 1 distant metastasis TNM stage |
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