Demonstration of mismatch negativity in the monkey. |
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Authors: | D C Javitt C E Schroeder M Steinschneider J C Arezzo H G Vaughan |
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Affiliation: | Department of Psychiatry, Albert Einstein College of Medicine, Bronx, NY 10461. |
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Abstract: | In humans, deviant auditory stimuli elicit an event-related potential (ERP) component, termed "mismatch negativity" (MMN), that reflects the operation of a cortical detector of infrequent stimulus change. Epidural auditory ERPs were recorded from 3 cynomolgous monkeys in response to soft and loud clicks. "Oddball" loud or soft stimuli elicited a long-duration frontocentral negativity, peaking at approximately 85 msec, that was superimposed upon cortically generated obligatory ERP components. These data suggest that monkeys might serve as a heuristically valuable system in which to study the neurochemical and neuroanatomical substrates of early context-dependent ERP generation. |
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