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Weight, body composition and handgrip strength among pulmonary tuberculosis patients: a matched cross-sectional study in Mwanza, Tanzania |
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| Authors: | PrayGod George Range Nyagosya Faurholt-Jepsen Daniel Jeremiah Kidola Faurholt-Jepsen Maria Aabye Martine G Jensen Lotte Jensen Andreas V Grewal Harleen M S Magnussen Pascal Changalucha John Andersen Aase Bengaard Friis Henrik |
| Institution: | a National Institute for Medical Research, Mwanza Centre, P.O. Box 1462, Mwanza, Tanzania b National Institute for Medical Research, Muhimbili Centre, P.O. Box 3436, Dar es Salaam, Tanzania c Department of Human Nutrition, Faculty of Life Sciences, University of Copenhagen, Rolighedsvej 30, DK-1958 Frederiksberg C, Denmark d Department of Infectious Diseases, Rigshospitalet, University of Copenhagen, Blegdamsvej 9, DK-2100 Copenhagen Ø, Denmark e The Gade Institute, Section for Microbiology and Immunology, University of Bergen and Haukeland University Hospital, Norway f DBL-Centre for Health Research and Development, Department of Veterinary Disease Biology, Faculty of Life Sciences, University of Copenhagen, Thorvaldsensvej 57, DK-1871 Frederiksberg C, Denmark |
| Abstract: | This study aimed to estimate deficits in weight, arm fat area (AFA), arm muscle area (AMA) and handgrip strength among smear-positive pulmonary TB (PTB+) patients starting treatment. We conducted a cross-sectional study among PTB+ patients and age- and sex-matched neighborhood controls. HIV status, anthropometric measurements and handgrip strength were determined. Deficits in weight, AFA, AMA and handgrip strength associated with PTB+ and HIV were estimated using multiple regression analysis.We recruited 355 pairs of PTB+ patients and controls. PTB+ was associated with deficits of 10.0 kg (95% CI 7.3; 12.7) in weight and 6.8 kg (95% CI 5.2; 8.3) in handgrip strength among females and 9.1 kg (95% CI 7.3; 10.9) in weight and 6.8 kg (95% CI 5.2; 8.4) in handgrip strength among males. In both sexes, PTB+ was associated with deficits in AFA and AMA. Among females, HIV was associated with deficits in AMA and handgrip strength, but the deficit in handgrip strength was larger among PTB+ patients (3.2 kg 95% CI 1.3; 5.2) than controls (-1.6 kg 95% CI -4.8; 1.5) (interaction, P = 0.009).These findings suggest that deficits in weight and handgrip strength among patients starting TB treatment are severe. Thus, nutritional support may be necessary to ensure reversal of the deficits, and may improve treatment outcomes. |
| Keywords: | pulmonary tuberculosis HIV weight body composition nutritional status handgrip strength |
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