|
|||||
|
|
High prevalence of toxinogenic Clostridium difficile in Nigerian adult HIV patients |
|
| Authors: | Onwueme Kenolisa Fadairo Yetunde Idoko Lucy Onuh James Alao Olu Agaba Patricia Lawson Lovett Ukomadu Chinweike Idoko John |
| Affiliation: | a Brigham and Women's Hospital, Boston, MA, USA b Obala Foundation, Boston, MA, USA c AIDS Prevention Initiative Nigeria at Jos University Teaching Hospital, Jos Nigeria d Zankli Medical Center, Abuja Nigeria |
| Abstract: | Clostridium difficile is the most commonly identified bacterial cause of nosocomial and HIV-related diarrhea. In many developing countries, antibiotic access is unregulated. Nigeria has the third highest HIV burden worldwide. Due to perceptions of low prevalence and resource incapacity, patients with diarrhea are not tested for toxinogenic C. difficile infection (CDI). In this pilot study which included 97 HIV-positive patients at two hospitals in Nigeria, the estimated prevalence of CDI was 43% and 14% for in-patients and out-patients respectively. HIV-positive out-patients were more likely to have toxinogenic CDI than non-HIV out-patients (P = 0.007, Fisher's exact test). |
| Keywords: | Clostridium difficile HIV Sub-Saharan Africa Nigeria Diarrhea |
| 本文献已被 ScienceDirect PubMed 等数据库收录！ | |