| 甲状腺激素β受体激动剂在代谢性疾病中的应用前景 |
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| 引用本文： | 王楠,冯凭. 甲状腺激素β受体激动剂在代谢性疾病中的应用前景[J]. 国际内分泌代谢杂志, 2008, 28(6) |
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| 作者姓名： | 王楠 冯凭 |
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| 作者单位： | 天津医科大学总医院代谢病科,300052 |
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| 摘 要： | 甲状腺激素β1受体(TRβ1)是甲状腺激素参与能量代谢、脂代谢和糖代谢的土要受体.TRβ激动剂选择性作用于TRβ1,动物实验表明TRβ激动剂KB-141、GC-1等可以减轻体重、调节血脂、改善精耐量、增加胰岛素的敏感性,不升高血压,且几乎不影响心率、骨骼肌和下丘脑-垂体-甲状腺轴的功能.凶此,TRβ激动剂有可能成为防治肥胖、血脂异常、糖尿病和代谢综合征等代谢性疾病的新药.
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| 关 键 词： | 甲状腺激素β受体激动剂 肥胖 血脂异常 糖尿病 代谢综合征 |
Perspective of β thyroid hormone receptor agonist in metabolic disease |
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| WANG Nan,FENG Ping. Perspective of β thyroid hormone receptor agonist in metabolic disease[J]. International JOurnal of Endocrinology and Metabolism, 2008, 28(6) |
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| Authors: | WANG Nan FENG Ping |
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| Abstract: | Thyroid hormone receptor β1(TRβ1)is the chief receptor by which thyroid hormone regulates the energy metabolism,lipid anti glucose metabolism.Thyroid hormone β receptor agonist(TRβ agonist),snch as KB-141,GC-1,selectively affects TRβ1.Animal experiments show that,rrRB agonist can reduce body weight,modulate lipids,improve glucose tolerance and insulin sensitivity,without significant effect on blood pressure,heart rate,skeletal mllSCle and hypothalamie-pituitary-thyroid axis.Therefore.TRβ agonist may become a new kind of dnJg for prevention and treatment of metabolic diseases such as obesity.dyslipidemia,diabetes and metabolic syndmme. |
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| Keywords: | Thyroid homlone β receptor agonist Obesity Dyslipidenfia Diabetes mellitus Metabolic syndrome |
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