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Outcome of HLA-matched related allogeneic hematopoietic stem cell transplantation for patients with acute leukemia in first complete remission treated in Eastern European centers. Better results in recent years |
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| Authors: | Sebastian Giebel Myriam Labopin Jerzy Holowiecki Boris Labar Mieczyslaw Komarnicki Vladimir Koza Tamas Masszi Martin Mistrik Andrzej Lange Andrzej Hellmann Antonin Vitek Joze Pretnar Jiri Mayer Piotr Rzepecki Karel Indrak Wieslaw Wiktor-Jedrzejczak Jerzy Wojnar Malgorzata Krawczyk-Kulis Slawomira Kyrcz-Krzemien Vanderson Rocha |
| Institution: | 1. Department of Clinical Oncology, Comprehensive Cancer Center, Maria Sklodowska-Curie Memorial Institute Branch Gliwice, Wybrzeze Armii Krajowej 15, 44-101, Gliwice, Poland 2. European Group for Blood and Marrow Transplantation, Acute Leukemia Working Party, Hopital Saint-Antoine, Assistance Publique des H?pitaux de Paris and Université de Paris 6, Pierre et Marie Curie, Paris, France 3. Department of Hematology, University Hospital Center Rebro, Zagreb, Croatia 4. Department of Hematology, University of Medical Sciences, Poznan, Poland 5. Department of Hematology and Oncology, Charles University Hospital Pilsen, Pilsen, Czech Republic 6. Department of Bone Marrow Transplantation, Szent László Hospital, Budapest, Hungary 7. Clinic of Hematology and Transfusion Medicine, University of Brastislava, Bratislava, Slovakia 8. Lower Silesian Center for Cellular Transplantation with National Bone Marrow Donor Registry, Wroclaw, Poland 9. Department of Hematology, Medical University of Gdansk, Gdansk, Poland 10. Institute of Hematology and Blood Transfusion, Prague, Czech Republic 11. Department of Hematology, University Medical Center Ljubljana, Ljubljana, Slovenia 12. Department of Internal Medicine, Hemato-Oncology, University Hospital Brno, Brno, Czech Republic 13. Bone Marrow Transplantation Unit, Military Medical Academy, Warsaw, Poland 14. Department of Hemato-Oncology, University Hospital Olomouc, Olomouc, Czech Republic 15. Department of Hematology and Oncology, Medical University of Warsaw, Warsaw, Poland 16. Department of Hematology and Bone Marrow Transplantation, Silesian Medical University, Katowice, Poland 17. Department of Hematology, Hopital Saint-Louis, Assistance Publique Hopitaux de Paris, Paris, France |
| Abstract: | The goal of this study was to analyze results and to determine factors affecting outcome of HLA-matched hematopoetic stem cells transplantation (MRD-HSCT) for patients with acute leukemia transplanted in first complete remission in Eastern European countries. Six hundred forty HSCT were performed between 1990 and 2006 for adults with acute myeloid (n = 459) and lymphoblastic (n = 181) leukemia. Two-year leukemia-free survival (LFS), nonrelapse mortality (NRM), and relapse incidence were 58 ± 2%, 19 ± 2%, and 23 ± 2%, respectively. The cumulative incidence of NRM decreased from 22 ± 2% for patients treated between 1990 and 2002 to 15 ± 3% for transplantations performed between 2003 and 2006 (p = 0.02), despite increasing recipient age. In a multivariate analysis, time of HSCT affected both NRM and LFS. Among other prognostic factors, the use of TBI decreased relapse incidence and increased the LFS rate. We conclude that results of MRD-HSCT for acute leukemia in Eastern Europe improved over time as a consequence of decreased NRM. The use of TBI containing regimens appears advantagous. On behalf of the Acute Leukemia Working Party of the European Group for Blood and Marrow Transplantation |
| Keywords: | Matched related donor HSCT Acute leukemia Prognostic factors Leukemia-free survival Nonrelapse mortality |
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