脑膜血管瘤病临床病理观察

目的：认识脑膜血管瘤病的临床病理表现和本质。方法：复习3例患者的临床病史,影像学表现及病理形态,免疫组化染色（ABC法）抗体包括：EMA,vimentin、SMA、GFAP、Syn及相关文献。结果：3例均为男性,2例为少年,均有癫痫发作,另1例为偶有头痛,均经CT或MRI扫描而发现病变,病变位于颞后近颞顶枕三角区的皮层内,皮层内充满围绕小血管生长的纤维母细胞样梭形细胞或脑膜上皮细胞,免疫组化染色EMA、vimentin阳性,有不同程度和数量的砂粒小体或钙化形成,病灶内残留神经细胞和胶质增生。结论：从病变的临床表现看,本组3例可能均属于散发型脑膜血管瘤病,而非2型神经纤维瘤病（NF2）相关病例。

Meningioangiomatosis:A report of 3 cases

Purpose To acknowledge the clinicopathological manifestation and the entity of meningioangiomatosis. Methods Expression of EMA, vimentin, SMA, GFAP and synaptophysin were detected by immunohistochemical stain using the ABC methods, with the review of the clinical history, radiologic features, histopathologic changes and related literatures. Results Three cases were male, in which 2 cases were young juveniles with epilepsy, and the another was adult with occasional headaches. The intracortical lesions were found in the posterior temporal lobes near the triangular areas by CT or MRI scanning. The intracortical lesion was characterized by a plaque like proliferation of meningiothelial and fibroblast like cells positive for EMA and vimentin surounding small vessels, forming variable psammoma bodies and calcifications. Some neuron and gliosis remained in the lesions. Conclusion Three cases reported here may be the sporadic type of meningioangiomatosis, rather than NF2 associated type of the disease.