利培酮和氟哌啶醇治疗精神分裂症的双盲对照研究

目的 比较利培酮和氟哌啶醇治疗精神分裂症的疗效及副作用。方法 采用双盲双模拟的研究方法,实验及统计结束后揭盲。疗效评定采用阳性和阴性症状量表(PANSS)、临床总体印象量表(CGI)及临床总体疗效四级评定标准。不良反应采用不良反应量表(TESS)和Simpson-Angus量表(SAS)。观察8周。结果 1)两组在PANSS和BPRS总分较治疗前显著降低(P<0.001)组间无显著性差异。2)两组治疗后PANSS减分率:氟哌啶醇组58.08±21.12％,利培酮组65.37±16.50％。两组间无显著性差异。3)总有效率;氟哌啶醇组64％,利培酮组74.07％。4)TESS表明:两组在失眠、头晕、口干、视物模糊、心动过速、体重增加等项严重程度无显著性差异,在肌强直、震颤、静坐不能等项,两组有显著性差异,利培酮组优于氟哌啶醇组。5)安坦合并用药率,利培酮组显著低于氟哌啶醇组(P<0.05)。结论利培酮和氟哌啶醇一样能有效治疗精神分裂症,但利培酮锥外系副作用更小。利培酮和氟哌啶醇都是有效、安全的抗精神病药物。

The double-blind study of risperidone and haloperidal in the treatment of schizophrenia

Objectives: To evaluate the efficacy and side effects of risperidone and haloperidal. Method: Subjects were assigned into 2 medication groups and assessed with the PANSS, CGI, TESS and Simpson-Angus (SAS) before and after treatment. The duration of observation is eight weeks. Results: 1) There are significant declines in the scores of PANSS after treatment (P<0. 001), but there isn't significant difference between two groups. 2) There aren't significant difference in positive and negative symptom scores. 3) TESS shows significant differences in myotonus, tremor, akathisia. Risperidone group is better than haloperidal group. Conclusion: risperidone and haloperidal have the same efficacy to schizophrenia. Risperidone has less extrapyramidal side effects.