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Fluctuating high urinary phenylethylamine excretion rates in some bipolar affective disorder patients |
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| Authors: | Farouk Karoum Markku Linnoila William Z Potter Lyn W Chuang Frederick K Goodwin Richard J Wyatt |
| Institution: | 1. Farouk Karoum, Ph.D., is Research Chemist, Adult Psychiatry Branch, National Institute of Mental Health (NIMH), USA;2. Markku Linnoila, M.D., Ph.D., is Staff Psychiatrist, Clinical Psychobiology Branch, NIMH, USA;3. William Z. Potter, M.D., Ph.D., is Chief, Clinical Psychopharmacology Unit, Clinical Psychobiology Branch, NIMH, USA;4. Lyn W. Chuang, M.S., is Chemist, Adult Psychiatry Branch, NIMH, USA;5. Frederick K. Goodwin, M.D., is Scientific Director, Intramural Research Program, NIMH, USA;6. Richard J. Wyatt, M.D., is Director, Division of Special Mental Health Research, NIMH, USA |
| Abstract: | Five women with primary major bipolar affective disorders had variable and at times very high urinary phenylethylamine (PEA) excretion rates. The clinical picture of these patients was characterized by periodic bizarre behaviors and short psychotic episodes. These patients were generally nonresponsive to the usual treatment modalities, and their symptoms were exacerbated by nonspecific monoamine oxidase inhibitors which further increased PEA excretion rates. |
| Keywords: | Bipolar affective disorder phenylethylamine psychotic behavior |
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