Elevation of erythrocyte glycine levels during lithium treatment of affective disorders |
| |
| Authors: | Seymour Rosenblatt William P. Leighton J.D. Chanley |
| |
| Affiliation: | 1. Seymour Rosenblatt, M.D., and William P. Leighton are at the Department of Psychiatry, USA;2. Chanley, Ph.D., is at the Department of Biochemistry, The Mount Sinai School of Medicine of the City University of New York, USA |
| |
| Abstract: | An elevation of erythrocyte (RBC) glycine was observed in a group of patients with bipolar affective disorder who were being treated with lithium (Li) carbonate. A maximal increase of 90% or more was generally attained after about 100 days of Li intake and was maintained for 2 years or longer. After 3 or more years of Li therapy, the RBC glycine had often returned to the normal range. Abrupt withdrawal of Li in such a case produced an immediate, dramatic, and paradoxical increase in RBC glycine which lasted for 100 days. Plasma glycine was not affected by Li. |
| |
| Keywords: | Erythrocyte (RBC) glycine lithium therapy affective disorders |
| 本文献已被 ScienceDirect 等数据库收录！ |
|
