2型糖尿病患者糖化血红蛋白和血脂检测及临床意义

目的检测2型糖尿病患者的糖化血红蛋白(HbAlc)、空腹血糖(FPG)、血脂水平并观察它们之间的关系及其临床意义。方法选择100例2型糖尿病患者进行HbAlc、FPG、TC、TG、LDL-C、HDL-C检测。糖化血红蛋白检测采用层析法;FPG检测采用葡萄糖氧化酶法;TC检测采用酶法(CHOD-PAP法);TG检测采用酶法(GHO-PAP法);低密度脂蛋白胆固醇(LDL-C)、高密度脂蛋白胆固醇(HDL-C)采用直接酶法。结果空腹血糖增高,糖化血红蛋白水平随之增高,二者呈显著正相关(P<0.01);甘油三酯(TG)、总胆固醇(TC)和低密度脂蛋白(LDL)随血糖和糖化血红蛋白值的上升而数值增大,呈正相关(P<0.05);高密度脂蛋白(HDL)随血糖和糖化血红蛋白值的上升反而逐渐减小,呈负相关(P<0.05)。结论糖尿病患者的血脂和糖化血红蛋白增高程度与血糖的增高有关;联合检测HbAlc和血脂对糖尿病早期预防诊断及治疗有重要意义和价值。

Glycosylated hemoglobin in patients with type 2 diabetes mellitus and blood lipids and its clinical significance

Objective To detect patients with type 2 diabetes glycated hemoglobin （HbALc）, fasting plasma glucose （FPG）, lipid levels and to observe the relationship between them and their clinical significance. Methods 100 cases of type 2 diabe tes diabetes group set. To HbA1c, FPG, TC, TG, LDL-C, HDL-c test. Glycated hemoglobin were detected by chromatography;FPG was measured with glucose oxidase ;TC were detected by enzymatic （CHOD-PAP method） determination ;TG detection method for the enzymatic （GHO-PAP method determination; low-density lipoprotein cholesterol（LDL- C）, high density lipoprotein cholesterol （HDL-C） direct enzymatic method. Results Increased the level of glycated hemoglobin, fasting blood glucose（FBG） levels increased subsequently, both showed a significant positive correlation （P 〈 0.01 ）; triglyceride （TG）, total cholesterol （TC）and low density lipoprotein （LDL）.With the blood glucose and glycated hemoglobin values rise in value increases, a positive correlation（P 〈 0.05）;high-density lipoprotein （HDL） with the blood glucose and glycated hemoglobin values increased but gradually decreased, showing a negative correlation （P 〈 0.05）. Conclusion Diabetic patients with elevated lipids and glycated hemoglobin levels and blood glucose increased related; combined detection of HbAlc and lipids of diabetes diagnosis and treatment of early prevention has an important meaning and value.