南通市体检人群中非酒精性脂肪肝患病情况及危险因素探讨

目的探讨南通市体检人群中非酒精性脂肪肝患病情况及其危险因素。方法从体检信息管理系统中抽取2011年47 571例体检者作为研究对象,对其肝脏超声、体重指数、血脂、空腹血糖、尿酸、肝功能、血压资料进行分析。结果非酒精性脂肪肝10 042例,患病率为21.11%。男患病率为27.16%,显著高于女患病率11.70%(P<0.001)。多因素Logistic回归分析显示,年龄、超重、高甘油三酰血症、高总胆固醇血症、低-高密度脂蛋白血症、高-低密度脂蛋白血症、高血糖症、高尿酸血症、ALT异常、GGT异常、SBP异常、DBP异常均可增加NAFLD的发病危险。结论年龄、性别(男性)、超重、高血脂、高血糖症、高尿酸血症、ALT异常、GGT异常、血压异常可能是非酒精性脂肪肝发病的危险因素。

Studies on prevalence and risk factors of non-alcoholic fatty liver disease among Nantong health check-up subjects

Objective To investigate the prevalence and the main risk factors of non-alcoholic fatty liver disease（NAFLD） among 47571 Nantong health check-up subjects. Methods Data of 47 571 health check-up subjects were investigated, including hepatic ultrasound, BMI,lipid [total cholesterol （TC）,high density lipoprotein cholesterol （HDL-C）,low density lipoprotein cholesterol （LDL-C）, and triglyceride （TG） ], fasting blood glucose （FBG）, uric acid （UA）, alanine amino- transferase （ALT）, γ -glutamyhransferase （GGT）, blood pressure[ （systolic blood pressure （SBP） and diastolic blood pressure （DBP）]. Results The prevalence of NAFLD was 21.11%. The prevalence of NAFLD was 27.16% of men,and 11.70% of women, the difference significant（P 〈 0.001 ）. Logistic regression analysis showed that several factors were associated with the risk of NAFLD,including age,overweight, hypertriglyceridemia（HTG）, hypercholesterolemia（HTC）, lower-HDL-C, hyper-LDL-C, hyper-FBG（HFBG）, hyper-UA（HUA）,abnormal ALT,abnormal GGT,abnormal SBP and abnormal DBP. Conclusion The main risk factors of NAFLD were age, overweight, HTG, HTC,L-HDL-c, H-LDL-c, abnormal ALT, ab- normal GGT, HUA, HFBG, abnormal SBP and abnormal DBP.