慢性静脉压增高状态下脑微循环的动态研究

目的 研究慢性静脉压增高状态下脑微循环的动态变化。方法 选择Wistar雄性大鼠16只,分为对照组A（n=6)和实验组B(n=10),全身麻醉下,A组单纯右颈总动脉结扎,B组右颈总动脉与右颈外静脉端端吻合。利用激光多普勒扫描技术测定吻合前、后以及2周后吻合部结扎前、后脑表25处局部脑血流（ICBF）和局部脑血流量（1CBV）的变化,区域脑血流（rCBF)和区域脑血流量（rCBV)分别用各自的25个数据的中位数表示。结果 A组的两侧大脑半球以及B组的左侧大脑半球吻合前后rCBF,rCBV的变化无统计学意义,B组的右侧大脑半球吻合前后rCBF,rCBV无统计学意义,但2周后rCBF显著降低（P＜0．05）,rCBV显著增高（P＜0．05）,吻合部结扎后rCBF即刻增高（P＜0．05）,rCBV即刻降低（P＜0．05）。结论 一侧颈总动脉一颈外静脉吻合模型对研究慢性静脉压增高状态下脑缺血的研究具有实用价值;在慢性静脉压增高状态下结扎动静脉短路后,脑灌注压迅速上升,CBF得到改善。

Hemodynamics of Chronic Venous Hypertension in Rat

Objective:To evaluated the changes of regional flow(rCBF)and cerebral blood volume(rCBV)in chronic venous hypertension model in rat.Method Venous hypertension was induced by an end to end anastomosis between the right carotid artery and the right extermal jugular vein.Local CBF(1CBF)and 1CBV at 25 locations were assessed by a modem laser Doppler "scanning" technique at 4 times before and after the fistula.The animals were classified two groups:group A(n=6)(the carotid artery occlusion only)and group B(n=10).Results In group A and the left hemisphere of group B,both of rCBF and rCBV didn't change.Howere,in the right hemisphere rCBV significantly increased 2 weeks after the bypass but recovered after clipping of the fistula(P<0 05),and rCBF significantly decreased 2 weeks after the bypass but recovered after clipping of the fistula(P<0 05).Conclusion In conclusion,the rat model of carotid jugular arteriovenous fistula is clinically relevant and useful for studying the pathophysiology of chronic venous hypertension.Venous ischemia is a reversible condition which can be improved by appropriate early stage treatment.