| 烧伤病人血清免疫抑制作用与氧自由基 |
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| 引用本文： | 谢有富,郭实士.烧伤病人血清免疫抑制作用与氧自由基[J].湖南医科大学学报,1998,23(1):103-105. |
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| 作者姓名： | 谢有富 郭实士 |
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| 作者单位： | [1]湖南医科大学附属湘雅医院烧伤科 [2]免疫研究室 |
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| 摘 要： | 观察１１例烧伤病人血清免疫抑制作用与氧自由基的关系。结果显示：烧伤病人血清ＭＤＡ，ｓＩＬ－２Ｒ升高（Ｐ〈０．０１），病人血清能抑制正常人ＰＢＭＣ产生ＩＬ－２（Ｐ〈０．０１），抗氧化治疗可降低病人血清ｓＩＬ－２Ｒ水平和血清的抑制作用（Ｐ〈０．０５）。提示氧自由基是烧伤病人血清免疫抑制作用的因素之一。
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| 关 键 词： | 烧伤 血清 免疫抑制 氧自由基 |
The relationship between immunosuppression and oxygen free radicals in burned patients] |
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| Y Xie,E Ma,S Guo.The relationship between immunosuppression and oxygen free radicals in burned patients][J].Bulletin of Hunan Medical University,1998,23(1):103-105. |
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| Authors: | Y Xie E Ma S Guo |
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| Institution: | Department of Burn and Plastic Surgery, Xiangya Hospital, Hunan Medical University, Changsha. |
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| Abstract: | The serum immunosuppression effect and its relation to oxygen free radicals were studied in patients with thermal injury (n = 11, total body surface area 20%-83%). The serum MDA, sIL-2R increased significantly in burned patients (P < 0.01 all). The serum of burned patients depressed the IL-2 productin of normal human PBMC (P < 0.01). Antioxidants decreased the serum sIL-2R in burned patients and attenuated the suppressive effect IL-2 production of normal human PBMC (P < 0.05 all). The results suggest that oxygen free radicals participate in the serum immunosuppression effect in burned patients. |
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