| 结肠腺瘤与腺癌p53,c—erbB2蛋白及CEA的表达和意义 |
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| 引用本文： | 徐杨 许淑媛. 结肠腺瘤与腺癌p53,c—erbB2蛋白及CEA的表达和意义[J]. 湖南医科大学学报, 1998, 23(2): 129-132 |
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| 作者姓名： | 徐杨 许淑媛 |
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| 摘 要： | 应用免疫组化法检测１５例正常结肠粘膜，４０例结肠瘤及４０例结肠癌组织的ｐ５３，ｃ－ｅｒｂＢ２和ＣＥＡ的表达。结果发现：结肠癌患者ｐ５３，ｃ－ｅｒｂＢ２及ＣＥＡ的阳性表达率均显著高于腺瘤（Ｐ〈０．０１）。ｐ５３阳性表达在不典型增生腺瘤患者中，重度显著高于轻度病例（Ｐ〈０．０１）；在结肠腺癌患者中低分化显著高于高分化病例（Ｐ〈０．０５）；ＣＥＡ的新型单克隆抗体ｃｏｌ－１对结肠癌的敏感性和特异性均高，阳
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| 关 键 词： | 结肠肿瘤 癌基因 腺瘤 腺癌 癌胚抗原 |
Expression and significance of p53, c-erbB2, CEA proteins in colorectal adenoma and carcinoma] |
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| M Shu,S Liu,P Yu. Expression and significance of p53, c-erbB2, CEA proteins in colorectal adenoma and carcinoma][J]. Bulletin of Hunan Medical University, 1998, 23(2): 129-132 |
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| Authors: | M Shu S Liu P Yu |
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| Affiliation: | Department of Microbiology, Hunan Medical University, Changsha. |
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| Abstract: | Expression of p53, c-erB2, CEA proteins in 15 cases of normal colorectal mucosa, 40 adenoma and 40 carcinoma of colon were studied with immunohistochemistry. The positive rate of p53, c-erbB2, CEA in colorectal carcinomas were significantly higher than those in adenoma. The positive rate of p53 in adenoma with severe atypical hyperplasia was higher than that in the mild (P< 0.01), and was higher in colorectal carcinomas of poor differentiation that that in the well-differentiated ones (P< 0.05). The novel type monoclonal antibody of CEA Col-1 had a high sensitivity and specificity for the tissue of colorectal carcinoma in which the positive rate was 85%. The results suggested the alteration p53, c-erbB2 are involve in the tumorgenesis and development of colorectal carcinoma; and detection of p53, c-erbB2 and CEA proteins are helpful in distinguishing benign and malignant polyps of colon. |
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