| 扶正保真汤对荷瘤鼠化疗增效实验研究 |
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| 引用本文： | 李京 黎杏群. 扶正保真汤对荷瘤鼠化疗增效实验研究[J]. 湖南医科大学学报, 1998, 23(5): 435-437 |
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| 作者姓名： | 李京 黎杏群 |
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| 摘 要： | 对荷人肺腺瘤（ＳＰＣ－Ａ），肉瘤（Ｓ１８０）ＢＡＬＢ／Ｃ小鼠采用扶正保真汤加环磷酰胺化疗合并治疗，与单用化疗组相比较。结果表明；扶正保真汤加化疗组抑瘤率较高（Ｐ〈０．０１）；且能升高瘤组织内ｃＡＭＰ水平，提高ｃＡＭＰ／ｃＧＭＰ值（Ｐ〈０．０５），增加Ｇ０＋Ｇ１期细胞，减少Ｓ期细胞（Ｐ〈０．０５）；降低血清ＴＮＦ－α水平及ＭＤＡ含量（Ｐ〈０．０１），提高Ｔ－ＳＯＤ活力（Ｐ〈０．０１）。提示扶正保真汤
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| 关 键 词： | 肿瘤移植 扶正保真汤 小鼠 中医药疗法 实验 |
Experimental study of FZBZ decoction enhancing chemotherapy efficacy for mice bearing with tumors] |
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| J Li,X Li,J Li,G Chen,X Li,X Zhang. Experimental study of FZBZ decoction enhancing chemotherapy efficacy for mice bearing with tumors][J]. Bulletin of Hunan Medical University, 1998, 23(5): 435-437 |
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| Authors: | J Li X Li J Li G Chen X Li X Zhang |
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| Affiliation: | Institute of Combined Traditional Chinese and Western Medicine, Hunan Medical University, Changsha. |
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| Abstract: | To study the mechanism of the increasing effect of Fuzheng Baozhen decoction (FZBZD) on chemotherapy. The BALB/C mice with transplanted human lung adenocarcinoma (SPC-A-1), sarcoma (S180) were treated in different groups. Comparing the group treated with chemotherapy (CTX), and the group treated with CTX plus FZBZD, the inhibiting tumor rate was higher (P < 0.01), the cAMP/cGMP ratio was increased by adding cAMP level in cancer tissue (P < 0.05), the level of serum TNF-alpha and MDA was decreased (P < 0.01), the activity of total SOD was improved (P < 0.01), the G0/G1 phase cells enhanced and S phase cells decreased in tumor tissue (P < 0.05). It suggested that FZBZD increased the effect of chemotherapy in different ways. |
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