| 湖南地区丙型肝炎病毒基因型在肝细胞癌组织中的分布 |
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| 引用本文： | 冯德云,谭德明.湖南地区丙型肝炎病毒基因型在肝细胞癌组织中的分布[J].湖南医科大学学报,1998,23(3):232-234. |
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| 作者姓名： | 冯德云 谭德明 |
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| 作者单位： | [1]湖南医科大学病理学教研室 [2]湖南医科大学附属湘雅医院传染科 |
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| 摘 要： | 采用型特异性引物ＰＣＲ分型法对５０例肝细胞癌组织中感染的丙型肝炎病毒（ＨＣＶ）进行基因分型。结果显示：单独ＨＣＶⅡ型感染为６０％（３０／５０）；单独Ⅲ型感染６％（３／５０）；感染为Ⅱ＋Ⅲ型１０％（５／５０），Ⅱ＋Ⅳ型为１６％（８／５０），Ⅱ＋Ⅰ＋Ⅲ型为４％（２／５０）；Ⅰ￣Ⅳ型均阴性的病例４％（２／５０）。表明湖南地区肝细胞癌患者的ＨＣＶ感染以Ⅱ型为主，并存在Ⅱ型与其它型的混合感染；少数病例可能系
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| 关 键 词： | 肝肿瘤 丙型肝炎病毒 基因型 聚合酶链反应 |
Genotype distribution of hepatitis C virus in hepatocellular carcinoma tissue in Hunan province] |
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| D Feng,H Zheng,R Cheng,D Tan.Genotype distribution of hepatitis C virus in hepatocellular carcinoma tissue in Hunan province][J].Bulletin of Hunan Medical University,1998,23(3):232-234. |
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| Authors: | D Feng H Zheng R Cheng D Tan |
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| Institution: | Department of Pathology, Hunan Medical University, Changsha. |
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| Abstract: | Genotypes of hepatitis C virus(HCV) were detected by PCR using type-specific primer in 50 patients' hepatocellular carcinoma(HCC) tissue. The results showed that in the 50 HCC specimens, 30(60%) and 3(6%) were infected with the HCV type II and III, 5(10%) and 8(16%) with type II + III and type II + IV, 2(4%) with type II + I + III in combination, respectively. 2 cases were negative for HCV. These data suggest that HCV type II may be a predominant genotype related to hepatocarcinogenesis in Hunan Province, some cases of HCC may result from coinfection of HCV type II and other genotypes, and only few HCC be separately caused by infection of HCV type III. |
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