| 高渗盐／甘露醇液对失血性休克兔心肌收缩能力和血压的影响 |
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| 引用本文： | 黄志军.高渗盐／甘露醇液对失血性休克兔心肌收缩能力和血压的影响[J].湖南医科大学学报,1998,23(3):249-251. |
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| 作者姓名： | 黄志军 |
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| 摘 要： | 应用家兔失血性休克模型，观察高渗氯化钠／甘露醇液（ＨＳＭ）、高渗醋酸钠／甘露醇液（ＨＡＭ）、高渗氯化钠，右旋糖酐液（ＨＳＤ）对其心肌收缩能力，动脉血压的影响。结果表明：三组高渗胶液仅小剂量能在很短时间内升高休克兔的左室内压、左室内压变化速率及动脉血压。ＨＳＭ对上述指标的影响较ＨＳＤ，ＨＡＭ更大（Ｐ〈０．０５），血压升高的时间与心肌收缩能力变化的时间同步，对高渗高胶液抗休克的机制进行了探讨。
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| 关 键 词： | 休克 失血性休克 高渗盐 甘露醇 心肌收缩能力 |
The effects of hypertonic saline/mannitol resuscitation on the myocardiac contractility and blood pressure of rabbits with hemorrhagic shock] |
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| Z Huang,X Luo,A Tang.The effects of hypertonic saline/mannitol resuscitation on the myocardiac contractility and blood pressure of rabbits with hemorrhagic shock][J].Bulletin of Hunan Medical University,1998,23(3):249-251. |
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| Authors: | Z Huang X Luo A Tang |
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| Institution: | Department of Emergency, Xiangya Hospital, Hunan Medical University, Changsha. |
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| Abstract: | Eighteen healthy adult male rabbits were hemorrhaged to shock and treated with hypertonic-hyperoncotic solutions in 3 groups (6 per group): hypertonic saline/dextran(HSD), hypertonic saline/mannitol(HSM) and hypertonic acetate/mannitol(HAM). The results showed that HSM. HAM and HSD could raise the left ventricular pressure(LVP), maximum change rate of LVP (+/- dp/dt max) and the arterial blood pressure of hemorrhagic shock rabbits quickly at small dose. The efficiency of HSM was better than that of HSD and HAM (P < 0.05), and the time of blood pressure rise was in accordance with that of LVP and +/- dp/dt max, which may partly explain the mechanism of shock resuscitation by hypertonic-hyperoncotic solution. |
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